AIM:To investigate the efficacy of a high-potency probiotic preparation on prevention of radiation-induced diarrhea in cancer patients. METHODS:This was a double-blind, placebo-controlled trial. Four hundred and ninety patients who underwent adjuvant postoperative radiation therapy after surgery for sigmoid, rectal, or cervical cancer were assigned to either the high-potency probiotic preparation VSL#3 (one sachet t.i.d. ,) or placebo starting from the first day of radiation therapy. Efficacy endpoints were incidence and severity of radiation-induced diarrhea, daily number of bowel movements, and the time from the start of the study to the use of loperamide as rescue medication. RESULTS:More placebo patients had radiation-induced diarrhea than VSL#3 patients (124 of 239 patients, 51.8%, and 77 of 243 patients, 31.6%; P < 0.001) and more patients given placebo suffered grade 3 or 4 diarrhea compared with VSL#3 recipients (55.4% and 1.4%, P < 0.001). Daily bowel movements were 14.7 ± 6 and 5.1 ± 3 among placebo and VSL#3 recipients (P < 0.05), and the mean time to the use of loperamide was 86 ± 6 h for placebo patients and 122 ± 8 h for VSL#3 patients (P < 0.001). CONCLUSION:Probiotic lactic acid-producing bacteria are an easy, safe, and feasible approach to protect cancer patients against the risk of radiation-induced diarrhea.

No abstract

In recent years, contrasting seismic tomographic images have given rise to an extensive debate about the occurrence and implications of migrating slab detachment beneath southern Italy. One of the most pertinent aspects of this process is the concentration of the slab pull force, and particularly its surface expression in terms of vertical motions and related basin subsidence/uplift. In this study we focused on shallow-water to continental, Pliocene-Quaternary basins that formed on top of the Apennine allochthonous wedge after its emplacement onto a large foreland carbonate platform domain (Apulian Platform). Due to the thick-skinned style of deformation controlling the Pliocene- Pleistocene stages of continental shortening, a high degree of coupling with the downgoing plate appears to characterize the late tectonic evolution of the southern Apennines. Therefore, the wedgetop basins analysed in this study, although occurring on the deformed edge of the overriding plate, are capable of recording deep geodynamic processes affecting the slab. Detailed stratigraphic work on these wedge-top basins points to a progressive SE-ward migration of basin subsidence from c. 4 to c. 2.8 Ma over a distance of about 140 km along the strike of the Apennine belt. Such a migration is consistent with a redistribution of slab-pull forces associated with the progressive lateral migration at a mean rate in the range of 12–14 cm y–1 of a slab tear within the down-going Adriatic lithosphere. These results yield fundamental information on the rates of first-order geodynamic processes affecting the slab, and on related surface response

No abstract

The flooding susceptibility of alluvial fans in the Southern Apennines has long been neglected. To partly address this oversight, we focus on the region of Campania which contains highly urbanized piedmont areas particularly vulnerable to flooding. Our findings are based on stratigraphic analysis of the fans and morphometric analysis of the basin‐fan systems. Using geomorphological analysis we recognized active alluvial fans while stratigraphic analysis together with statistical analysis of the morphometric variables was used to classify the fans in terms of the transport process involved. The results indicate that in the geological context examined, the best discrimination between debris flow (Df) and water flood (Wf) processes is achieved by means of two related variables, one for the basin (feeder channel inclination, Cg) and one for the fan (fan length, Fl). The probability that an unclassified fan belongs to group Wf is computed by applying a logistic function in which a P value exceeding 0.5 indicates that a basin/fan system belongs to group Wf. This important result led to the classification of the entire basin/fan system data. As regards process intensity, debris flow‐dominated fans are susceptible to the occurrence of flows with high viscosity and hence subject to more severe events than water flood‐dominated fans. Bearing this in mind, the data gathered in this study allow us to detect where alluvial fan flooding might occur and give information on the different degrees of susceptibility at a regional scale. Regrettably, urban development in recent decades has failed to take the presence of such alluvial fans into account due to the long recurrence time (50–100 years) between floods. This paper outlines the distribution of such susceptibility scenarios throughout the region, thereby constituting an initial step to implementing alluvial fan flooding control and mitigation. Copyright © 2012 John Wiley & Sons, Ltd.

No abstract

Archaeological excavations, undertaken since 2004 for the construction of the new Naples subway, have unearthed the harbor basin of the Greco–Roman town of Parthenope–Neapolis, furnishing scientists with the opportunity to recover abundant archaeological remains and a thick succession of diverse infill sediments. The latter underwent sedimentological, paleontological, and volcanological analyses. Compositional data analysis, applied to all three data sets, highlighted three main paleoenvironmental changes in the harbor basin from the Augustan Age up to the 6th century A.D. The beginning of harbor activity is recorded during the 3rd century B.C. when sedimentation was interrupted by intensive dredging of the sea‐bottom. The impact of the A.D. 79 Vesuvius eruption, recorded for the first time in the Neapolitan territory, led to a reduction in Posidonia meadows and to an ensuing phase of more restricted water circulation and pollution. At the beginning of the 5th century A.D., an open lagoon environment was established, attesting to coastal progradation. The final closure of this part of the bay occurred at the end of the 5th to the beginning of the 6th century A.D., due to increased alluvial input linked to both natural and anthropogenic causes.

A basin-scale, integrated approach, including sedimentological, geomorphological and soil data, enables the reliable reconstruction of the infilling history of the southern Apenninic foredeep, with its subsequent inclusion in the wedge-top of the foreland basin system. An example is shown from the Molise-Apulian Apennines (Southern Italy), between Trigno and Fortore rivers, where the Pleistocene tectono-sedimentary evolution of the basin is framed into a sequence-stratigraphic scheme. Specifically, within the traditional subdivision into Quaternary marine (Qm) and Quaternary continental (Qc) depositional cycles, five third-order depositional sequences (Qm1, Qm2, Qc1, Qc2 and Qc3) are identified based on recognition of four major stratigraphic discontinuities. The lower sequence boundaries are represented by angular unconformities or abrupt facies shifts and are generally associated with distinctive pedological and geomorphological features. Three paleosols, observed at top of depositional sequences Qm2, Qc1 and Qc2, represent pedostratigraphic markers that can be tracked basinwide. The geomorphological response to major tectonosedimentary events is marked by a series of paleosurfaces with erosional, depositional and complex characteristics. Detailed investigation of the relationships between stratigraphic architecture and development of unconformities, paleosols and paleosurfaces suggests that the four sequence boundaries were formed in response to four geomorphological phases/tectonic events which affected the basin during the Quaternary. The first three tectonic events (Lower-Middle Pleistocene), marking the lower boundaries of sequences Qm2, Qc1 and Qc2, respectively, are interpreted to be related to the tectonic regime that characterized the last phase of thrusting recorded in the Southern Apennines. In contrast, sequence Qc3 does not display evidence of thrust tectonics and accumulated as a result of a phase of regional uplift starting with the Middle Pleistocene.