NAVIGATOR is an Italian regional project boosting precision medicine in oncology with the aim of making it more predictive, preventive, and personalised by advancing translational research based on quantitative imaging and integrative omics analyses. The project’s goal is to develop an open imaging biobank for the collection and preservation of a large amount of standardised imaging multimodal datasets, including computed tomography, magnetic resonance imaging, and positron emission tomography data, together with the corresponding patient-related and omics-related relevant information extracted from regional healthcare services using an adapted privacy-preserving model. The project is based on an open-source imaging biobank and an open-science oriented virtual research environment (VRE). Available integrative omics and multi-imaging data of three use cases (prostate cancer, rectal cancer, and gastric cancer) will be collected. All data confined in NAVIGATOR (i.e., standard and novel imaging biomarkers, non-imaging data, health agency data) will be used to create a digital patient model, to support the reliable prediction of the disease phenotype and risk stratification. The VRE that relies on a well-established infrastructure, called D4Science.org, will further provide a multiset infrastructure for processing the integrative omics data, extracting specific radiomic signatures, and for identification and testing of novel imaging biomarkers through big data analytics and artificial intelligence.
The paper aims to analyse how European Union law and the jurisprudence of the EU Court of Justice currently influence the interpretation of the Italian Constitution and, at the same time, whether there are still limits to the 'internationalisation' and 'Europeanisation' of national constitutional laws that are relevant for the analysis of the Constitution. Until 2001, there was no mention in the Italian Constitution of the European Union or the interaction between the national and the European legal system. Following the 2001 reform, a reference to European Union law was introduced in Article 117 of Italian Constitution, and the relationship between the Italian Constitutional Court and EU law changed entirely. For many years, it had been based on the theory of counter-limits (Italian Constitutional Court judgments in Frosini n. 173/1973 and Granital n. 170, 5 June 1984). As an example of the new relationship mentioned above, we use the Italian Constitutional Court's approach to renewable energy policy.
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