The synthesis of 3,4-ethylene-bridged 1,1,2,5-tetrasubstituted biguanides is reported, which are accessible by three alternative routes. Exemplary molecular structures of the ligand and an observed side product have been elucidated by X-ray diffraction analysis. Mono-and dinuclear complexes of the biguanide in both its neutral and monoanionic forms were obtained, including examples of aluminum, copper, magnesium, potassium, tin, and zinc, indicating a versatile coordination behavior, as evidenced by means of single-crystal X-ray diffraction analysis.Article pubs.acs.org/IC
A facile and efficient one‐pot strategy for the preparation of 1,2,3‐tri‐ and 1,1,2,3‐tetrasubstituted bis(guanidine)s by starting from from readily available bis(thiourea)s has been successfully developed. The reaction provides products that contain a range of terminal and bridging groups. After a simple workup procedure, the products were obtained in analytically pure and in good to excellent yields.
The ring-opening polymerization grand prix: Bis(amidinate)s outpaced their bis(guanidinate) competitors and won the race, while the drivers’ engines using acidic co-initiators collapsed before take-off.
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