The goal of the present work is to describe the Oncogenome model of cancer development, according to which viruses and intracellular bacteria benefit from continuous cell division. Unlimited division of the host cells means unlimited expansion of the living space and possibility for unlimited multiplication of viral и bacterial particles. We call oncogenomes those viruses and bacteria, which could evolve to acquire an ability to affect the System of regulation of cell division. We discuss which genes and systems have to be affected by viruses and bacteria to trigger the unlimited proliferation of the host cells. Data regarding the effect of 9 viruses and 8 bacteria on cell are given. It is suggested that the main reason of cancer development is oncogenome microevolution, which takes place during chronic infection. This microevolution allows oncogenomes to overcome cell resistance and gain the control over cell division, leading to cancer incidence and development.
Pathogenic fungi attack plants at any phase of development from the seedling stage to the seed maturing stage. The microflora found on seeds can be both pathogenic and saprotrophic. Some saprotrophs, including micromycetes of the storage period, such as Penicillium spp., under certain conditions are able to pass to parasitism, causing mold of the seed. On the other hand, Penicillium spp. is known to play an important role in soil fertilization and stimulation of plant growth. Identification of Penicillium spp. during eggplant ontogenesis «from seed to seed» was done. Several eggplant genotypes of local selection were used in the study. Molecular analysis using nested-PCR and a set of primers designed for species-specific regions of the Penicillium genome: P. chrisogenum, P. expansum, P. citrinum, P. verrucosum, P. griseofulvum, P. brevicompactum was performed. The identification of the pathogens of genus Penicillium in the seeding material, in the leaves collected at different stages of plant development and in seeds isolated at the phase of biological maturity of the fruits was carried out.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.