The objective of this study was to evaluate the influence of different sources and doses of organic and mineral fertilization on the production of green-leaf lettuce. The experiment design used randomized blocks in a factorial scheme (6×3), with six doses of fertilizers (1 = 0; 2 = 25; 3 = 50; 4 = 100; 5 = 150, and 6 = 200% of the recommended fertilization for green-leaf lettuce crop) and three sources of fertilizers [cattle manure (CaM) and chicken manure (ChM), decomposed, on a wet basis and applied 100% at planting at the doses: CaM – 0, 12.5, 25, 50, 75, 100 Mg ha-1; ChM – 0, 5, 10, 20, 30, 40 Mg ha-1; mineral fertilization (MF) varying the N levels: 0, 37.5, 75, 150, 225, 300 kg ha-1 plus 400 kg ha-1 of P2O5 and 60 kg ha-1 of K2O]. The fertilization with CaM and ChM was more efficient than the MF at increasing the production of green-leaf lettuce, mainly because of  the higher residual effects of P in the Oxisol. The ChM provided a higher soil pH, P and K, while the CaM provided a higher soil Mg, organic carbon and organic matter. The dose with 144% of organic fertilization exclusively on a wet basis corresponding to 72 Mg ha-1 of CaM and 29 Mg ha-1 of ChM resulted in the highest green-leaf lettuce yield.