The work reports facile synthesis of novel ten α-aminophosphonate derivatives coupled with 3-formyl chromone moiety, namely diethyl ((4-oxo-4H-chromen-3-yl)((5-sustituted phenyl-1,3,4-thiadiazol-2-yl)amino)methyl)phosphonate 6(a-j). The derivatives 6(a-j) were synthesized through one-pot three component Kabachnik-Fields reaction, by using ultrasound in presence of zirconium oxychloride (ZrOCl2) as a catalyst, to give the final compounds in better yields and in shorter reaction time. Thiadiazole and its derivatives possess a broad range of biological and pharmacological properties. 5-substituted phenyl-1,3,4-thiadiazol-2-amine is widely used as starting material for the synthesis of a broad range of heterocyclic compounds and as substrates for drug synthesis. Several 3-formylchromone derivatives possess a broad range of biological and pharmacological properties. The α-amino phosphonate derivatives constitute an important class of organophosphorus compounds on account of their versatile biological activity.Considering the importance of the three pharmacophores, promoted us to club all pharmacophores in a single molecule using green protocol. The Principles of Green chemistry are followed while performing the synthesis.
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