BACKGROUND:Obesity has frequently been associated with the dyslipidemic state and with the risk of various chronic diseases.OBJECTIVE:The objective of this study was to determine the relationship between obesity and blood lipids with a risk of colorectal cancer (CRC).METHODOLOGY:Histologically confirmed CRC patients from five local hospitals were matched with cancer-free controls for age, gender, and ethnicity (n = 140: 280). The study participants underwent physical assessment for the presence of obesity and 10 mL of fasting blood was drawn for blood lipid analysis.RESULTS:In this study, abdominal obesity significantly doubled the risk of CRC (adjusted odds ratio [AOR] =1.69, 95% confidence interval [CI] = 1–2.83). Hypercholesterolemia and low high-density lipoprotein cholesterol (HDL) increased the risk of CRC more than twofolds (AOR = 2.6, 95% CI = 1.7–3.9 and AOR = 3.8, 95% CI = 2.3–6.3, respectively). Abdominal obesity and hypercholesterolemia synergically doubled the risk of CRC (AOR = 2.0, 95% CI = 1–4). Low-HDL has shown no synergic association with other dyslipidemic states with an increased CRC risk.CONCLUSION:Improving abdominal obesity, hypercholesterolemia, and low HDL may be a clinically relevant strategy to reduce the risk of CRC among Malaysians.

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These data hypothesized that simple measurement of abdominal obesity, abnormal BP and HDL-cholesterol especially using International Diabetes Federation (IDF) definition of MetS for South Asians for to detect individuals at CRC risk may have higher clinical utility than applying other universal complex MetS definitions.

PurposeThis study aimed to determine the relationship between calorie and macronutrients intake and the growth status of Aboriginal children based on gender and age group.Design/methodology/approachThis was a cross-sectional study participated by 85 school-aged Aboriginal children at Labu, Negeri Sembilan. The dietary intake and socioeconomic status data were collected from the parents using an interviewer administrated structured-questionnaire and 24-hour dietary recall. WHO AnthroPlus software was used to determine the z-score of weight for age (WAZ), height for age (HAZ) and body mass index (BMI) for age (BAZ).FindingsThe mean fat intake was significantly higher among younger children (i.e. 7–9 years old) as compared to elder children (i.e. 10–12 years old) (40.7 ± 17.3 g vs 32.0 ± 13.8 g; t = 2.496, p = 0.015) but not for the mean intake of calorie (1816.1 ± 979.9 kcal vs 1566.3 ± 808.7 kcal; t = 1.248, p = 0.216), protein (50.13 ± 20.08 g vs 44.94 ± 16.45 g; t = 1.269, p = 0.208) and carbohydrates (198.0 ± 63.0 g vs 190.8 ± 66.1 g; t = 0.513, p = 0.609). The majority of the respondents did not meet recommended nutrient intake (RNI) for the calorie (65.9%) and fat (75.3%). A significantly higher proportion of elder children did not meet RNI for fat as compared to younger children (88.8% vs 65.3%; X2 = 6.21, p = 0.021). The HAZ showed that 28.2% (n = 24) of the Aboriginal children were stunted, while WAZ showed that 14.8% (n = 9) of the Aboriginal students were underweight, and 8.2% of them were overweight. Based on BAZ classification, 15.4% (n = 6) of boys and 2.2% (n = 1) of girls were overweight. There is no significant correlation between calories and macronutrients and growth status of the children.Originality/valueAlthough the under-nutrition status among Aboriginal children is still a highlighted issue, the few over-nutrition statuses among Aborigines should be taken into count, especially in term of energy and macronutrient intake.

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Nitric oxide (NO), a reactive nitrogen species, is a molecule of high physiological as well as pathological importance. Physiological mechanisms mediated by NO mainly include angiogenesis, growth, puberty and senescence. NO has vital roles in normal reproduction, including steroidogenesis, gametogenesis and the regulation of germ-cell apoptosis. In females, NO stimulates an inflammatory cascade to induce ovulation, decreases steroidogenesis in luteal and granulosa cells, and acts as a paracrine factor to mediate reproductive cycles and implantation. In males, NO is a key player for steroidogenesis, erectile functions, sperm capacitation and acrosome reaction. Moreover, NO is also a regulator of Sertoli cell-germ cell interaction and maintenance of the blood-testis barrier. In pathological conditions such as infections, increased nitric oxide synthase (NOS) activities stimulate the excessive synthesis of NO which acts as a proinflammatory mediator inducing oxidative stress (OS), which is detrimental to reproductive functions in both males and females. During impregnation, the overproduction of NO results in uterine epithelial cell inflammation and immune rejection of implantation. Excessive NO synthesis disrupts gonadal functions, and induces germ cell apoptosis and oxidative damage to the germ cells. This review elucidates how the differences in NO expression levels account for its beneficial and adverse impacts upon male and female fertility.

Background: One of the key importance of vegetable consumption is to obtain sufficient micronutrients, dietary fibre, and for the prevention of childhood obesity. Most Malaysian children did not meet the recommended intake of vegetable consumption, and this is especially vulnerable among the urban poor population due to food insecurity. Efforts are needed to promote vegetable consumption that fall short of the recommended intake level. Aim: This trial aims to examine the effectiveness of the “GrowEat” project, as a nutrition intervention programme integrated with home gardening activities to improve vegetable consumption among urban poor children in Kuala Lumpur, Malaysia. Methods: This is a single-blinded parallel two-arm cluster randomised controlled trial (RCT) that include 134 children. Two zones in Kuala Lumpur will be randomly selected, and three low-cost housing flats from each zone will be selected as the intervention and control groups respectively. The trial is designed based on the social cognitive theory (SCT). Children from the intervention group ( n = 67) will attend a 12-week programme, which consists of home garden-based activities, gardening and nutrition education session. Assessment will be conducted for both groups at three time points: baseline, post-intervention and follow-up phase at 3 months after the intervention. Conclusion: We anticipate positive changes in vegetable consumption and its related factors after the implementation of the “GrowEat” project. The current intervention may also serve as a model and can be extended to other urban poor population for similar interventions in the future to improve vegetable consumption, agriculture and nutrition awareness.

Colorectal cancer (CRC) is ranked as the third most common cancer and second deadliest cancer in both men and women in the world. Currently, the cure rate and 5-year survival rate of CRC patients remain relatively low. Therefore, discovering a novel molecular biomarker that can be used to improve CRC screening, diagnosis, prognosis, and treatment would be beneficial. Long non-coding RNA colon cancer-associated transcript 1 (CCAT 1) has been found overexpressed in CRC and is associated with CRC tumorigenesis and treatment outcome. CCAT 1 has a high degree of specificity and sensitivity, it is readily detected in CRC tissues and is significantly overexpressed in both premalignant and malignant CRC tissues. Besides, CCAT 1 is associated with clinical manifestation and advanced features of CRC, such as lymph node metastasis, high tumor node metastasis stage, differentiation, invasion, and distant metastasis. In addition, they can upregulate oncogenic c-MYC and negatively modulate microRNAs via different mechanisms of action. Furthermore, dysregulated CCAT 1 also enhances the chemoresistance in CRC cells while downregulation of them reverses the malignant phenotypes of cancer cells. In brief, CCAT 1 serves as a potential screening, diagnostic and prognostic biomarker in CRC, it also serves as a potential therapeutic marker to treat CRC patients.