In this paper, an initial feature vector based on the combination of the wavelet packet decomposition (WPD) and the Mel frequency cepstral coefficients (MFCCs) is proposed. For optimizing the initial feature vector, a genetic algorithm (GA)-based approach is proposed and compared with the well-known principal component analysis (PCA) approach. The artificial neural network (ANN) with the different learning algorithms is used as the classifier. Some experiments are carried out for evaluating and comparing the classification accuracies which are obtained by the use of the different learning algorithms and the different feature vectors (the initial and the optimized ones). Finally, a hybrid of the ANN with the 'trainscg' training algorithm and the genetic algorithm is proposed for the vocal fold pathology diagnosis. Also, the performance of the proposed method is compared with the recent works. The experiments' results show a better performance (the higher classification accuracy) of the proposed method in comparison with the others.
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