Background:
Staphylococcus aureus fibronectin-binding protein A (FnBPA) binds fibronectin and fibrinogen at adjacent sites.Results: The fibrinogen-binding mechanism is similar but not identical to homologous bacterial proteins. Ternary complex formation by intact fibronectin and fibrinogen on adjacent FnBPA sites could not be demonstrated.Conclusion: Fibrinogen binding is sterically regulated by fibronectin binding.Significance: Steric regulation might result in targeting of S. aureus to fibrin clots.
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