Introduction: The aim of this study was to compare the shear bond strengths of zirconia to dentin using two resin-based luting cements and a resin-modified glass-ionomer cement (RMGIC). Materials and Methods: Thirty six zirconia blocks of 2 mm × 3 mm × 5 mm were milled and luted to the exposed dentin surfaces and grouped into three according to the cement used for luting: Group I – luted with Panavia F2.0, Group II – luted with RelyX U200, and Group III – luted with FujiCEM. After thermocycling, specimens were subjected to shear bond testing in an Universal Testing Machine (UTM). Data analysis using Kruskal–Wallis ANOVA and post hoc Mann–Whitney U -test with P < 0.05 was done. Results: Mean bond strengths were of the order Panavia F2.0 (5.99 MPa)>RelyX U200 (4.79MPa)>FujiCEM (1.59 MPa). Maximum failures were at the zirconia-cement interface and were adhesive in nature. Conclusions: It can be concluded with the study that there is a better bonding of zirconia to dentin with resin-based luting cements than a RMGIC. The single-step resin-luting cement RelyX U200 produced comparable bond strength to that of a multistep Panavia F2.0.

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Background: Andrographispaniculata(AP) and Carica papaya(CP) are extensively distributed in South India and traditional healers use these plant preparations for treating various disorders including fever. Individual studies on AP & CP have shown that both have anti-pyretic property. However, it is not known what would be the effect when both the extracts are given together. Hence this study was undertaken.Objectives:To evaluate the anti-pyretic activity of aqueous extract of Andrographispaniculata & Carica papaya individually and in combination in rats. To compare the anti-pyretic activity of aqueous extract of Andrographispaniculata & Carica papaya individually and in combination with that of paracetamol in rats.Methods:48 adult male rats were divided in to 8 groups of 6 animals each. Fever was induced by injecting Brewer's yeast subcutaneously. Control group received normal saline 10ml/kg, standard group paracetamol 150mg/kg and the 6 test groups received AP 100mg/kg, 200mg/kg, CP 100mg/kg, 200mg/kg and AP with CP 100mg/kg and 200mg/kg. Rectal temperature was measured at baseline, 1, 2, 3, and 4 hours. Results: Individual plant extracts of AP & CP significantly reduced the body temperature when compared to control (P<0.05). The combination of AP & CP 200mg/kg had shown significant reduction in body temperature which was comparable to standard drug paracetamol. CP had better antipyretic activity when compared to AP at 200mg/kg (P<0.05).Conclusion:The combination of both the plant extracts had better antipyretic action compared to individual plant extract and the antipyretic activity of the combination was comparable to paracetamol.

This acute oral toxicity study of Vipro TM Polyherbal Formulation was done in Wistar albino rats according to the OECD (Organization for Economic Co-operation and Development) guidelines (OECD NO.423) for acute toxicity studies. Six female rats were selected for the study and prior to dose administration, animals were fasted (feed withheld but not water) approximately for 18 hours. A limit dose of 2000 mg/ kg body weight of Vipro TM with distilled water was administered to first set of three rats as single oral dose. After dosing, the animals were fasted for approximately 3 hours. The rats were observed for 14 consecutive days after dosing.

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