Study design:A prospective clinical study of posterior lumbar interbody fusion in grade I and II degenerative spondylolisthesis was conducted between Mar 2007 and Aug 2008.Purpose:The objective was to assess the clinicoradiological profile of structural v/s nonstructural graft on intervertebral disc height and its consequences on the low back pain (LBP) assessed by Visual analog score (VAS) score and oswestry disability index (ODI) . This study involved 28 patients.Inclusion criteria:Age of 30–70 years, symptomatic patient with disturbed Activities of daily living (ADL), single-level L4/L5 or L5/S1 grade I or grade II degenerative spondylolisthesis.Exclusion criteria:Patients with osteoporosis, recent spondylodiscitis, subchondral sclerosis, visual and cognitive impairment and all other types of spondylolisthesis. All the patients underwent short-segment posterior fixation using CD2 or M8 instrumentation, laminectomy discectomy, reduction and distraction of the involved vertebral space. In 53.5% (n = 15) of the patients, snugly fitted local bone chips were used while in 46.4% (n = 13) of the patients, cage was used. Among the cage group, titanium cage was used in nine (32.1%) and PEEK cages were used in four (14.2%) patients. In one patient, a unilateral PEEK cage was used. The mean follow-up period was 24 months. Among the 28 patients, 67.8% (n = 19) were females and 32.14% (n = 9) were males. 68.24% (n = 18) had L4/L5 and 35.71% (n = 10) had L5/S1 spondylolisthesis. 39.28% (n = 11) were of grade I and 60.71% (n = 17) were of grade II spondylolisthesis.Conclusions:There was a statistically significant correlation (P < 0.012 and P < 0.027) between the change in disc height achieved and the improvement in VAS score in both the graft group and the cage group. The increment in disc height and VAS score was significantly better in the cage group (2 mm ± SD vis-a-vis 7.2 [88%]) than the graft group (1.2 mm ± SD vis-a-vis 5 [62 %]).
Dapsone is useful for treating a variety of infectious, immunological and hypersensitivity disorders. Commonly encountered adverse effects of this drug include dose unrelated (idiosyncratic) skin hypersensitivity reactions and dose-related haemolytic anemia and methemoglobinemia. Dapsone Hypersensitivity Syndrome (DHS) can be considered as a manifestation of DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) syndrome. DRESS is an adverse reaction that can be seen with the use of many drugs such as dapsone, sulfonamides, allopurinol, cyclosporine, azathioprine, minocycline, antiviral drugs, anticonvulsant and gold salt. This report refers to 45 year old female patient was brought to the hospital with chief complaints of Fever chills and rash all over the body since 1 week. One year prior to current admission she was prescribed with dapsone 100 mg/day on suspection of leprosy and found the hypersensitivity reaction on usage of dapsone for 4 weeks. We report a case on Dapsone syndrome with skin rashes all over the body and fever and effectively treated with Corticosteroids.
Aim: Cardiovascular disease (CVD) is a major health problem throughout the world and a common cause of premature morbidity and mortality. CVD is a general category of diseases that affects the heart and the circulatory system. The main aim of the study is to assess the prescribing pattern in geriatrics with cardiovascular diseases using beers criteria.
Study Design: Prospective observational study.
Results and Discussion: Total 132 patients, 12 dropouts due to lack of information. Out of 120 patients 69 Patients are identified as Male Patients and 51 Patients are Female. In 120 sample size Maximum No of Cases were found with Ischemic Heart disease (30.8%) Followed by myocardial infarction (24%) coronary artery disease (20%) congestive heart failure (13.3%) Unstable Angina (11.6%). In 120 Sample Size, Male Patients are Suffering More with Complications Compared to Female Patients.
Conclusion: In this Study with Assessing the Prescribing Pattern in Geriatrics with Cardio Vascular Diseases It was found that major complications seen in Male and Female Patients are Ischemic heart Disease with Left ventricular dysfunction Myocardial Infarction, Coronary Artery Disease, Angina, Congestive Cardiac Failure.
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