Background: Urosepsis means a severe infection of urinary tract (UTI) and/or male genital tract (prostate) with features consistent with systemic inflammatory response syndrome. UTI may occur among all the age groups and produce a broad range of clinical syndromes ranging from asymptomatic bacteriuria to acute pyelonephritis with gram negative sepsis to septic shock. It is estimated that the mortality rate due to urosepsis ranges from 30 to 40 p.c respectively. Urosepsis may also cause multiple organ dysfunction, hypoperfusion or hypotension. Urosepsis due to percutaneous nephrolithotomy may be catastrophic despite prophylactic antibiotic coverage and negative midstream urine culture and sensitivity testing (C&S) and bacteria in the stone can be responsible for systemic infection. The aim of the study is to compare bladder urine (culture & sensitivity) and collecting system urine and stone (culture and sensitivity) in predicting urosepsis following percutaneous nephrolithotomy. Subjects and Methods: A hospital-based, analytical prospective clinical study was conducted among thirty cases who were present during the study period and had undergone percutaneous nephrolithotomy (PCNL). Cases were included irrespective of gender with renal calculi in whom percutaneous nephrolithotomy was about to be done at Narayana Medical College & Hospital, Chintareddypalem, Nellore, Andhra Pradesh during 1st February 2014 to 31st January 2015. Data collected was divided into three main groups Midstream urine (C&S); Pelvic urine (C&S); and Stone (C&S) respectively. Data obtained was entered in Microsoft Excel-2013 and analyzed in SPSS version-22 trial. Appropriate statistical tests were applied and p-value less than 0.05 was considered as significant. Results: Bladder urine (C&S) was positive in 3/30 (10.00%) patients, Pelvic urine (C&S) in 5/30 (16.66 %) patients and Stone (C&S) in 8/30 (26.66 %) patients. Most of the infected specimens grew Escherichia coli followed by pseudomonas, klebsiella, enterococcus. Systemic Inflammatory Response Syndrome (SIRS) was reported among 26.7 p.c (8) of the patients. In one patient (3.33%) septic shock developed but no deaths were reported. Conclusion: Stone (C&S) and Pelvic urine (C&S) are better predictors of urosepsis than Bladder urine (C&S).
<p class="abstract"><strong>Background: </strong>Viscosupplementation is frequently used as a therapeutic strategy to manage patients with early osteo-arthritis of knees. A case series was followed up for a period of one year to study the clinical efficacy of intra-articular hyaluronic acid injections in different Kellegren Lawrence grades of osteoarthritis knee.</p><p class="abstract"><strong>Methods:</strong> 76 patients with primary osteoarthritis of knee not responding to analgesics, Quadriceps strengthening exercises, superficial and deep heat modalities were recruited after meeting inclusion criteria. They were followed up till the end of one year at an interval of every four months. Seventy patients completed the study and were analyzed for pain, stiffness and physical function using WOMAC osteoarthritis index. WOMAC scores were documented at initial consultation and follow up visits at the end of fourth, eighth and twelfth month.<strong></strong></p><p class="abstract"><strong>Results:</strong> Patients with Grade 1 and 2 osteoarthritis knee showed improvement in pain, stiffness and physical function following viscosupplementation lasting for one year. Those with Grade 3 osteoarthritis knee initially revealed good pain relief, enhanced function clinically till the second follow up. After that majority of the patients with Grade 3 osteoarthritis demanded for another session of viscosupplementation and expressed worsening of their knee symptoms. In Grade 4 osteoarthritis knee viscosupplementation found to be clinically and statistically ineffective. Adverse reactions following intra-articular hyaluronic acid injections included pain in five patients, pain and swelling in three patients, and injection site erythema in one patient.</p><p class="abstract"><strong>Conclusions:</strong> Viscosupplementation is a good therapeutic strategy in management of Grade 1-2 osteoarthritis knee. Intra-articular hyaluronic acid injections in Grade 3 osteoarthritis knee helps in delaying surgical intervention. It is in effective in Grade 4 osteoarthritis knee.</p>
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