Nucleophilic substitution is the most common way for introducing ['8F]fluorine into various molecules either by direct exchange with a leaving group of precursor or using small prosthetic groups. Radionuclide "F is produced in the form of [''Flfluoride by proton irradiation of ["0]H20 in a water cyclotron target. A standard procedure for preparing fluorinating agent involves activation step of ["Flfluoride by aminopolyether K2.2.2 (kryptofix) [1,2]. In the most of production methods the preceding step is the ["flfluoride adsorption on the anion exchange resin followed by its elution with an aqueous potassium carbonate o r complex mixture of
Aroylamidines can be obtained as salts in a reaction of the corresponding arylcarbonitriles with anhydrous ethanol in the presence of dry HCl followed by treating intermediate imidoesters with alcoholic solution of ammonia. N-Arylbenzamidines are obtained by reacting benzonitrile with arylamines in the presence of AlCl 3 . The structure of arylamines and the reaction conditions signifi cantly affect the yield of the target product, and sometimes the very possibility of its preparation.
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