Copper-rutin complex (2 mg/kg) completely eliminated epileptiform potentials induced by a combination of chlorpromazine and microwave radiation 1-2 min postinjection and suppressed convulsive activity provoked by application of penicillin to the sensorimotor cortex.
In experiments with urethane-anesthetized rabbits, the alteration in the activity of posterior hypothalamic neurons resulting from intracerebroventricular injection of leucocyte pyrogen was attenuated by subsequent administration of arecoline. Atropine failed to alter the neuronal response to leucocyte pyrogen but abolished the effect of arecoline. The neuronal response to arecoline was reversed in the absence of leucocyte pyrogen.
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