The effect of multilayer thin-film wound coatings upon regeneration of skin in its deep damage was studied 18 Chinchilla rabbits. Full-layer skin wounds 40 x 40 mm were inflicted on the back of the animals. In experimental group of animals the wounds were closed by multilayer coatings consisting of 50 aluminum metalized lavsan films. In control group one layer coating with thin aluminum plate was used. In all control animals the pyonecrotic wound processes developed within 1 — 2 weeks after intervention. In experimental rabbits the wound healing process showed no clinical signs of inflammation. In 6 weeks a full value regenerate in the zone of deep skin damage was formed. Its thickness and structure was typical of normal skin. Principle of multilayer coatings is perspective for the elaboration of coatings at treatment of deep and small wounds of various etiology when high quality of dermal regenerate is required.
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