The required compounds N-aryl-N'-(3-chloro-2-benzo[b]thenoyl)-thioureas 1a-k were prepared by condensing 3-chloro-2-benzo[b]thenoyl chloride with different arylamines using ammonium thiocyanate, which in turn when treated with chloroacetic acid, yielded 1-aryl-3-(3-chloro-2-benzo[b]thenoyl)thiohydantoins 2a-k, while in the presence of sodium acetate treated with chloroacetic acid, yielded 2-arylimino-3-(3-chloro-2-benzo[b]thenoyl)-4-thiazolidinones 3a-k. All the synthesized compounds were screened for their antitubercular and antimicrobial activities. Some selected compounds were selected for their further antitubercular screening.
Ring closure reactionsRing closure reactions O 0130 Synthesis of 4-Thiazolidinones and 2-Azetidinones Bearing Benzo(b)thiophene Nucleus as Potential Antitubercular and Antimicrobial Agents. -The title compounds (III), (V), and (VII) show antimicrobial activity. -(THAKER, K. M.; KACHHADIA, V. V.; JOSHI*, H. S.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 42 (2003) 6, 1544-1547; Dep. Chem., Saurashtra Univ., Rajkot 360 005, India; Eng.) -C. Oppel 40-055
Synthesis and Biological Activity of 3-Aryl-5-(3'-bromo/chlorophenyl)isoxazoles. -A variety of the title isoxazoles (IV) (20 examples) are synthesized and evaluated for their antitubercular and antimicrobial activities. A multiplicity of these heterocycles show significant activities. -(POPAT, K. H.; NIMAVAT, K. S.; KACHHADIA, V. V.; JOSHI*, H. S.; J. Indian Chem. Soc. 80 (2003) 7, 707-708; Dep. Chem., Saurashtra Univ., Rajkot 360 005, India; Eng.) -H. Toeppel 37-125
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