Nanocrystalline cerium oxide (CeO 2 ) is considered as one of the most promising inorganic materials for biomedical purposes. The unique redoxactivity, high biocompatibility and low toxicity of CeO 2 nanoparticles open great prospects in their biomedical usage as a therapeutic agent, including acceleration of skin regeneration processes after injuries of various etiologies. As part of this work, a hydrogel based on natural polysaccharides modified with CeO 2 nanoparticles was synthesized and its therapeutic efficacy in the treatment of planar full thickness and linear skin wounds in rats was shown. Basing on wound surface area measurements, results of skin wounds tensiometry and histological analysis it was found that polysaccharide hydrogel significantly reduces planar and linear wound healing times. Polysaccharide hydrogel modified with CeO 2 nanoparticles facilitates rapid reduction of wound defect area and the scar formation with complete tissue regeneration in the wound area. Additionally, composite hydrogels reduce the manifestations of non-specific signs of inflammation and intoxication. Thus, polysaccharide hydrogel modified with CeO 2 nanoparticles can be regarded as an effective wound healing substance in the therapy of skin injuries of various etiologies.
The corrosion resistance and electrochemical properties of titanium, zirconium and binary alloys of the whole zirconium-titanium system in highly aggressive electrolyte have been extensively studied and a number of interesting relationships have been found. The dependence of the course of electrochemical processes on the compositions of the alloy and the electrolyte have been shown. The alloy compositions and the ranges of concentration and temperature of solutions have been established within which the alloys have high corrosion resistance and may be employed as constructional materials for chemical plant.
This paper is aimed at the experimental study (in animal models) of acute toxicity and irritating properties of polysaccharide hydrogel modified with cerium oxide nanoparticles. In the acute experiment, there were no indications of irritating action of the gel at the site of application when the hydrogel was administered intragastrically or epicutaneously. No lethal effects were registered during this experiment even at the highest concentration. The results obtained demonstrate the lack of acute toxicity and local irritability of the synthesized hybrid hydrogel, which allows to classify the developed hybrid hydrogel as the relatively low-risk drug.
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