The screening study of the effects of several new diethylamino- and dimethylaminoethanol fumaric esters with Krebs cycle intermediates on the physical performance of male mice in the forced swimming test have been conducted. The compounds: Fumarate-DMAE-Fumarate at a dose of 75 mg/kg and Fumarate-DEAE-Succinate at a dose of 10 mg/kg, as well as Diethylaminoethanol (DEAE base) at a dose of 50 mg/kg. The study has shown that their effect on physical performance surpassed the comparison drug, deanol aceglumate, used at the optimal dose of 50 mg/kg. The latter provided a 74% increase in the maximum swimming time of animals, while the studied compounds showed +175%, +162%, +121% results compared to control. The actoprotective activity of the compounds Fumarate-DMAE-Fumarate (75 mg/kg dose) and Fumarate-DEAE-Succinate (FDES) (10 mg/kg dose) is comparable to the effect of ethylthiobenzimidazole hydrochloride (25 mg/kg dose).
The antihypoxic activity of a new benzimidazole derivative with dicarboxylic acid under histotoxic hypoxia was studied. It was established that the studied pharmacological agent at a dose of 25 mg/kg increases the life expectancy of animals by 2 times compared with the control group, 1.3 times compared to ethylthiobenzimidazole hydrochloride and 1.2 times compared to ethylmethylhydroxyperidine succinate.
In a narrowing beam-walking test, on the 21st day after the occlusion of the middle cerebral artery, it was found that the succinic salt of diethylaminoethanol fumaric ester (PDES), at doses of 10 and 75 mg/kg, led to a statistically signifi cant decrease in the severity of sensorimotor defi cit of the anterior and posterior contralateral limbs of male rats under the conditions of cerebral ischemia. The test substance at a dose of 10 mg/kg reduced the volume of ischemic damage to the cerebral cortex of rats by 1.5 times. In terms of neuroprotective activity, the effect of the succinic salt of diethylaminoethanol fumaric ester at a dose of 10 mg/kg is comparable to that of Citicoline at a dose of 500 mg/kg.
The effect of Eleutherococcus senticosus, Rhaponticum carthamoides and Schisandra chinensis extracts in doses of 10, 25, 50 and 75 mg/kg were studied. The actoprotective activity the studied adaptogens was assessed on outbred female mice in a forced swim test with a load of 10% of the animal's body weight. Dry extracts of Eleutherococcus senticosus (50 mg/kg), Rhaponticum carthamoides (10 mg/kg) and Schisandra chinensis (25 mg/kg) were found to exhibit the most pronounced actoprotective activity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.