Background: Cardiac marker enzymes are measured to evaluate the heart function. The diagnosis of acute myocardial infarction can be achieved by electrocardiogram (ECG) changes and elevation of cardiac marker enzymes like creatine kinase, lactate dehydrogenase (LDH), aspartate transaminase (AST) and troponin I. Objective: To estimates the levels of AST and troponin I among patients of acute myocardial infarction, and to compare with those among health controls. Materials and Methods: This study was carried out among 50 cases of acute myocardial infarction and 50 age and sex matched healthy individuals. Serum samples of cases, collected after 5 hours and within 24 hours from the onset of chest pain and of controls were analyzed for AST by modified IFCC method and for troponin I by chemiluminescence-sandwich method. Results: The mean levels of AST and troponin I in cases and controls revealed that mean levels of AST and cardiac troponin I in cases (296.02±SD 135.69 IU/L and 57.34±SD 12.83 ng/ml, erspectively) are significantly higher than among controls (25.50±SD 6.22 IU/L and 0.31±SD 0.15 ng/ml, respectively). The differences between cases and controls are statistically significant (p<0.0001). Conclusion: The diagnostic efficiency of AST and troponin I were superior because they are specific to myocardial injury.
Background: Hospitalization for Heart Failure (HF) is increasing in India. Diabetes Mellitus (DM) is closely related to HF. Hb1Ac is an index of metabolic control of DM. Hb1Ac is associated with increased risk of Acute Decompensated Heart Failure (ADHF). The relation between Hb1Ac and ADHF is less well defined.Aims and Objectives: The aim of the study was to find out the prevalence of ADHF among patients admitted for cardiac complaints and to investigate Hb1Ac levels in confirmed patients.Materials and Methods: A hospital based study was conducted at NRI Heart Centre, NRI General Hospital, Guntur from May to July 2013 after institutional ethical approval. All patients of ADHF were included in the study. Patients were analysed for HbA1c.Results: Out of 1147 patients admitted in Coronary Care Unit, there were 101 cases of ADHF giving a prevalence of 8.8%. The mean age was found to be 54.69 years. 19.8% of the patients were of age less than 40. There were 74.3% males and 25.7% females. The mean HbA1c in non diabetic, pre-diabetic and diabetic was 5.32%, 6.0% and 8.45% respectively.Conclusion: Elevated HbA1c is associated with increased morbidity in the heart failure and efforts should be made to treat these patients with proven therapies to lower the blood glucose levels.Asian Journal of Medical Sciences Vol.7(4) 2016 55-58
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