The fruit of Phoenix pusilla Garetn. has been used in herbal medicines, as it is sweet, sour, cooling and laxative, cardiotonic, aphrodisiac, carminative and roborant. The objective of the present study was to investigate the antioxidant and antidiabetic effect of ethanolic extract of unripe fruit of Phoenix pusilla in streptozotocin-induced diabetic rats. The extract was analyzed for the presence of various phytoconstituents like tannins, flavonoids, vitamin C, vitamin E, protein, carbohydrates, lipids and phenolic compounds. Streptozotocin (40 mg/kg body weight, i.p.) was administered to induce diabetes in adult rats. The extract (100 and 200 mg/kg) and glibenclamide (6 mg/kg) were administered orally for 21 days to evaluate antioxidant and antidiabetic activity. Blood glucose, serum total cholesterol and triglycerides levels were estimated. Carbohydrate and lipid metabolizing enzymes glucose-6-phosphatase, fructose-1,6-diphosphatase, glycolytic enzymes like hexokinase and liver-function enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx), production of thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALP), renal-function markers like urea and creatinine level were also measured. Histopathology of pancreas was studied. The results indicated that extract normalized the blood, liver, renal and pancreatic functions in streptozotocin-induced diabetic rats. Hence it can be concluded that the extract possesses antioxidant and antidiabetic activity. The findings support the conventional usage of Phoenix pusilla unripe fruit in treating diabetes.
Objective: The aim of the present study was to investigate the hepatoprotective effect of Livplus (a polyherbal formulation) against CCl 4 -induced hepatotoxicity in rats. Methods: Hepatotoxicity was induced in rats by i.p. injection of CCl 4 once three days for 14 days. Livplus or Silymarin was administered along with CCl 4 and the biochemical parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkalinephosphatase (ALP), total bilirubin (TB), direct bilirubin, total protein (TP), gamma-glutamyl transferase (GGT), total cholesterol (TC) and triglycerides (TG) were estimated. Furthermore, biomarkers of oxidative stress such as MDA levels, Glutathione contents, SOD and catalase activity in liver tissue were estimated. Results: Treatment with Livplus significantly reduced the elevated levels of ALT, AST, ALP, bilirubin (direct and total), GGT, TC, TG and increased levels of TP compared to CCl 4 control rats. The treatment with Livplus also showed a significant increase in glutathione contents, SOD and catalase activity and a decrease in MDA levels compared to CCl 4 control rats. Conclusion: The finding of present study indicates that Livplus showed a potential hepatoprotective activity. These results support the traditional use of Livplus in the treatment of liver disorders.
The present study was aimed to investigating the antioxidant activity of the ethanolic extract of Anogeissus acuminate was studied by using different invitro methods such as DPPH scavenging assay and Hydrogen peroxide scavenging (H 2 O 2 ) assay. The ethanolic extract of the plant 500µg/ml had shown potent activity in DPPH assay and Hydrogen peroxide scavenging assay. The findings suggest that the ethanol extract of Anogeissus acuminate is a effective free radical scavenger, augmenting its therapeutic value.
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