Reconstructive surgery remains inadequate for the treatment of volumetric muscle loss (VML). The geometry of skeletal muscle defects in VML injuries varies on a case-by-case basis. Three-dimensional (3D) printing has emerged as one strategy that enables the fabrication of scaffolds that match the geometry of the defect site. However, the time and facilities needed for imaging the defect site, processing to render computer models, and printing a suitable scaffold prevent immediate reconstructive interventions post-traumatic injuries. In addition, the proper implantation of hydrogel-based scaffolds, which have generated promising results in vitro, is a major challenge. To overcome these challenges, a paradigm is proposed in which gelatin-based hydrogels are printed directly into the defect area and cross-linked in situ. The adhesiveness of the bioink hydrogel to the skeletal muscles was assessed ex vivo. The suitability of the in situ printed bioink for the delivery of cells is successfully assessed in vitro. Acellular scaffolds are directly printed into the defect site of mice with VML injury, exhibiting proper adhesion to the surrounding tissue and promoting remnant skeletal muscle hypertrophy. The developed handheld printer capable of 3D in situ printing of adhesive scaffolds is a paradigm shift in the rapid yet precise filling of complex skeletal muscle tissue defects.

Since some years, there is a worldwide trend to move towards ''higher-fidelity'' simulation techniques in reactor analysis. One of the main objectives of the research in this area is to enhance the prediction capability of the computations used for safety demonstration of the current LWR nuclear power plants through the dynamic 3D coupling of the codes simulating the different physics of the problem into a common multi-physics simulation scheme.In this context, the NURESAFE European project aims at delivering to the European stakeholders an advanced and reliable software capacity usable for safety analysis needs of present and future LWR reactors and developing a high level of expertise in Europe in the proper use of the most recent simulation tools including uncertainty assessment to quantify the margins toward feared phenomena occurring during an accident. This software capacity is based on the NURESIM European simulation platform created during FP6 NURESIM project which includes advanced core physics, two-phase thermal-hydraulics, fuel modeling and multi-scale and multi-physics features together with sensitivity and uncertainty tools. These physics are fully integrated into the platform in order to provide a standardized state-of-the-art code system to support safety analysis of current and evolving LWRs.

No abstract

No abstract

SUBCHANFLOW is a computer code to analyze thermal-hydraulic phenomena in the core of pressurized water reactors, boiling water reactors, and innovative reactors operated with gas or liquid metal as coolant. As part of the ongoing assessment efforts, the code has been validated by using experimental data from the NUPEC PWR Subchannel and Bundle Tests (PSBT). The database includes single-phase flow bundle outlet temperature distributions, steady state and transient void distributions and critical power measurements. The performed validation work has demonstrated that the two-phase flow empirical knowledge base implemented in SUBCHANFLOW is appropriate to describe key mechanisms of the experimental investigations with acceptable accuracy.

No abstract

No abstract

Positron lifetime measurements were performed for two different kinds of polymers (low density polyethylene and a polyimide 6FDA-TMPD) during sorption of various vapors (hexane, cyclohexane, benzene, acrylic acid, methyl acrylate, water, and oxygen). The vapor sorption affected the long-lived component (ortho-positronium component) in a systematic way regardless of the kind of the vapor molecules, i.e. for the polyethylene both the lifetime and the intensity of the long-lived component were enhanced, while for the polyimide they were decreased significantly. These different effects are interpreted in terms of different states of sorbed molecules in rubbery (the polyethylene) and in glassy (the polyimide) polymers.