Separation of end fractions of given compositions from azeotropic mixtures is complicated by thermodynamic and topological constraints, which can be surmounted using the principle of redistribution of concentration fields between separation regions [1][2][3]. This principle can be implemented using homogeneous and heterogeneous (involving extraction, adsorption, absorption, and chemical and other separation techniques) separation systems. In homogeneous systems, distillation can be designed so that, at one of the steps, an azeotropic fraction is isolated, which is then separated by special methods. If this fraction contains two or more components, one can use extractive distillation or separation of the azeotropic mixture at different pressures. If the fraction contains more than two components, separation can be performed by methods using the curvature of the separating manifold [3,4]. Previously [2, 5], a general approach to synthesizing flowsheets for distillation of multicomponent nonideal (including azeotropic) mixtures was put forward, which is based on the concept of a distillation region. Later [6][7][8], some approaches to synthesizing flowsheets for distillation of multicomponent mixtures containing a single binary azeotrope were proposed, which use separation of an azeotropic mixture at different pressures.Note that, in practice, thermodynamic and topological constraints on separation of end fractions of given compositions are most often surmounted by using extractive distillation. However, conventional extractive distillation methods are highly energy-intensive. Therefore, it is topical to develop and use optimal energy-saving technologies. This problem is solved in several steps: structural optimization of a flowsheet, optimization of the operating parameters of distillation columns, design optimization of flowsheet elements. Since distillation is irreversible, its thermodynamic efficiency depends on the process path-a set of flowsheets or distillation trajectories. To date, approaches to synthesizing extractive distillation flowsheets have been developed obviously insufficiently. This question was considered only in few works. For example, a number of systems of different structures for separation of multicomponent azeotropic mixtures were proposed [9]. Certain technological solutions for distillation of an Abstract -An algorithm for synthesizing extractive distillation flowsheets for separation of complex ternary azeotropic mixtures with different vapor-liquid equilibrium patterns is proposed.