Inhibin biosynthesis by human prostatic tissue was investigated in vitro. Serum levels of inhibin as well as tissue concentrations in different cells and zones of the normal and benign hyperplastic prostates were determined. Immunocytochemical localization of inhibin identified the involvement of epithelial but not stromal cells in the synthesis and release of prostatic inhibin into the circulation. The endocrine and paracrine functions of prostatic inhibin remain to be elucidated.
Distribution of immunoreactive inhibin like material (IR-ILM) in different regions of human prostate was studied by using specific radio-immunoassay. Mean IR-ILM concentrations in the central, peripheral and periurethral zones were 27.3 k 9.3, 2.4 f 0.7 and 3.0 k 1.5 pg/mg protein respectively (P central vs periurethral and peripheral < 0.05).
Verteilung von immunreaktivem Inhibin-ahnlichem-Material in verschiedenen Regionen der menschlichen ProstataZusammenfassung : Mittels eines spezifischen RIA wurde die Verteilung eines immunreaktiven Inhibin-iihnlichen Materials in verschiedenen Partien der menschlichen Prostata untersucht. Im zentralen Prostataabschnitt ergab sich ein Mittelwert von 27,3 (k 9,3 pg/ mg), in der Peripherie von 2,4 (f 0,7 pm/mg) und im periurethralen Bereich von 3,O (* 1,s pg/mg). Die statistische Berechnung ergab fur das Zentrum: periurethral und peripher p = 0.05.
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