ABSTRACT. Complexes of Mn(II), Fe(III), Co(II), Ni(II) and Zn(II) with an intermediate Schiff base derived from ninhydrin and a,L-alanine (indane-1,3-dione-2-imine-N-2-propionate, IDIP) were successfully synthesized. All complexes were distinctly colored and were characterized by elemental analysis, molar conductance, magnetic susceptibility, infrared and electronic spectral studies. The ligand (Schiff base) was shown to behave as a monobasic tridentate ONO donor. The Mn(II) and Fe(III) complexes contain only one ligand molecule plus water and chloride(s) per metal ion, while all the others contain two ligand molecules per metal ion. An octahedral geometry is proposed for the metal complexes.A comparative anti-microbial study of the complexes was undertaken against two gramnegative bacteria, Escherichia coli and Proteus mirabilis and one gram-positive bacterium Staphylococcus aureus. It was revealed that most of the complexes and particularly Mn(II), Fe(III) and Co(II) complexes, have a much enhanced activity relative to ninhydrin against Proteus mirabilis and Staphylococcus aureus. All complexes showed a reduced activity against Escherichia coli.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.