Background Despite the current standard of concurrent chemoradiation (CCRT), around 30–40% are still dying from locally advanced cervical cancer. Increasing the radiation dose further was not a feasible option, but addition of chemotherapy further was tried due to the different toxicity profiles of it. So, the use of consolidation chemotherapy beyond CCRT has been studied. Aim To evaluate the efficacy, toxicity, tumour response and loco-regional control following consolidation chemotherapy after concurrent chemoradiation in locally advanced carcinoma cervix (LACC). Methods The patients were randomized into two arms: the conventional arm (control arm, n = 30) patients received conventional treatment with weekly injection cisplatin (35 mg/m 2 ) concurrently with pelvic external beam radiation (50 Gy/25 fraction, 2 Gy/fraction, 5 fraction weekly) followed by intracavitary radiotherapy of 21 Gy in 3 fractions of 7 Gy each by HDR brachytherapy. In the interventional arm (study arm, n = 30), patients received the standard treatment followed by 3 cycles of consolidation chemotherapy (paclitaxel + carboplatin) every three weekly. Results Haematological toxicity (grade 3 anaemia and grade 1 leucopenia, grade 1 and 2 thrombocytopenia) was higher in the study group. Renal, hepatic and gastrointestinal toxicity was more in the study arm. Peripheral neuropathy was mostly seen in the study arm. Median follow-up was 9 months. Treatment response was better, and the rate of recurrence was less in the study arm. Conclusion Addition of few cycles of consolidation chemotherapy after standard treatment is beneficial in patients with LACC with manageable toxicity and good compliance.
Skin cancers are uncommon in India with less than 1% incidence and among all sites of occurrence, waist line as a site of occurrence is again uncommon. This could be mostly attributed to the attire among men and women in India. Saree and dhoti are still the traditional costumes among Indian women and men respectively. Wearing them tight around the waist leads to pigmentation, scarring and ulceration. Repeated trauma leads to subsequent malignant transformation. The usage of terms ‘saree cancer ‘ and ‘dhoti cancer’ is less commonly seen nowadays eventhough it was proposed long back in 1945 and has been unknown to many in the recent times with very few papers published in mainstream medical journals. Herein, we report a case series of 12 patients with waistline cancer who presented at our centre between January 2001 till December 2020.
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