The present study was carried out with the objectives of assessing oxidative stress in dogs with chronic kidney disease (CKD) and evaluating response to treatment with N-acetyl cysteine (NAC). Dogs diagnosed with stage III CKD as per the guidelines of the International Renal Interest Society (IRIS) were included in the study. The animals were divided into two groups. Animals of one group were given standard therapy for CKD and the animals of the second group were administered NAC along with standard therapy. Oxidative stress parameters such as total antioxidant status (TAS), serum malondialdehyde (MDA) level and plasma glutathione peroxidase (GSH-Px) activity were studied. On the day of presentation, a significant increase in the mean values of serum MDA and TAS were observed in diseased animals compared to healthy animals, whereas a significant decline was noted in plasma GSH-Px activity. After treatment, a significant decline in serum MDA and TAS were recorded in animals of group II receiving NAC therapy. A significant increase in plasma glutathione GSH-Px activity was recorded in this group. N-acetyl cysteine therapy was found to be effective in the management of oxidative stress in dogs with chronic kidney disease.
Present study was conducted in Kerala Veterinary and Animal Sciences University farms, various organized and unorganised farms and individual households in Thrissur district during the period of May 2021 to April 2022 with the objectives of estimation of prevalence of subclinical ketosis (SCK) by screening dairy cows on 14th and 28th day post-partum. Multiparous cows with a blood beta-hydroxy butyrate (BHB) value ≥ 1.2 mmol/L without any overt clinical signs were considered as positive for SCK. One hundred and fourteen animals from second to seventh lactation were screened for SCK. Prevalence of SCK was 23.7 per cent on 14th day and 14.04 per cent on 28th day with a total prevalence of 27.2 per cent. Occurrence of SCK was highest in animals in second lactation (54.8 per cent) with more occurrence in crossbred Holstein Friesian cows. Maximum number of positive cases were observed in dairy cows of age between four to six years (54.8 per cent). Body condition score of diseased animals were higher than normal animals. Prevalence was highest in animals calved between months of July to September and 58.1 per cent of affected animals had male calf. Concurrent abnormalities during transition period were also assessed based on clinical examination and farm records.
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