Assessing accurately the pH of axillary eccrine sweat is of vital importance in the antiperspirant industry. Eccrine sweat pH is a critical parameter in determining the effectiveness of antiperspirants; antiperspirant salts dissolve in sweat and diffuse into the sweat glands, where the resultant acidic solution hydrolyses in more alkaline sweat forming an amorphous metal hydroxide gel, thereby restricting the flow of eccrine sweat. Comparison of the skin surface and sweat pH of males and females reported in the literature shows that, although consistent male/female differences have been observed on the forearm, determination of significant gender-based pH differences across other sites are less conclusive. Studies on the back and infra-mammary regions exhibited significant gender differences in skin surface pH, whereas those on the forehead, cheek, neck and inguinal area showed no such difference. With regard to the axilla specifically, four studies have been reported, three showing no significant difference in axillary skin surface pH and one indicating that females have an eccrine sweat pH of 7 and males have a sweat pH of 5.6. This paper describes a series of carefully controlled studies aimed at assessing potential gender differences in eccrine sweat and skin surface pH following exposure to a variety of temperature, humidity and time conditions. The results highlight the importance of controlling precisely the time of investigation, site of measurement and, most importantly, the necessity to pre-equilibrate samples in 40 mmHg carbon dioxide (equivalent to arterial CO(2) tension (pCO2)) before determining sweat pH. When these parameters are controlled no gender differences in axillary sweat or skin surface pH are observed. Large differences in eccrine sweat and skin surface pH are found, however, between the vault (hairy region) and fossa (non-hairy region) of the axilla.
Shaving the axilla is a regular part of the personal care regime for many women in Europe, North and South America. To assess the impact of shaving on underarm skin, a series of investigations were carried out, in which the thickness of the axillary vault and fossa were measured using optical coherence tomography (OCT), and underarm shaving debris was collected for study. The response of the axilla to histamine iontophoresis was also investigated. Additionally, a study was carried out to investigate the impact of a novel anti-perspirant roll-on formulation on irritation and self-perceived sensory properties of the axilla. The results clearly demonstrate that shaving the underarm consistently removes skin (stratum corneum) as well as axillary hair (with a mean value of 36.1% of the debris being skin). OCT measurements demonstrated that in shaved areas of the axilla, epidermal thickness is higher than in unshaved areas. In response to histamine, wheal and flare were both found to be greater in the shaved axilla, when compared with an unshaved control, but flare in the fossa was greater than that in the vault. On the basis of these results, we propose that the axillary vault has adapted to frequent shaving, notably by the development of a thickened epidermis. However, this adaptation is often not sufficient to fully protect the axilla from damage and irritation resulting from hair removal (shaving). In these instances, we have demonstrated that use of a novel anti-perspirant roll-on formulation containing glycerol and sunflower seed oil was able to reduce the impact of shaving-induced irritation and improve self-assessment of axillary condition.
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