Forty‐one patients with hormone refractory metastatic breast carcinoma were treated with 5‐day courses of methotrexate alone or in combination with androgens and/or prednisone. Of 33 who received at least three courses of methotrexate, 15 achieved objective remissions which lasted for an average of 9 months. There were no significant differences in frequency or duration of responses in the group treated with methotrexate alone and those treated with methotrexate plus androgens and/or prednisone. Subjective remissions were seen in an additional 11 patients.
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