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A series of antitumor compounds combining cytotoxic and estrogen action have been synthesized on the basis of 11b-acyloxyestra-1,3,5(10)-trienes. The corresponding synthons, 11b-hydroxy derivatives of estrone, estradiol, and ethynylestradiol, were obtained by oxidative nitration of 3-mono-and 3,17-diesters of these estrogens with ceric ammonium nitrate into the corresponding 9a-hydroxy-and 11b-nitroxy analogs with subsequent hydrogenolysis of the 9-hydroxy groups and removal of the nitrate protecting groups. 111 0091-150X/08/4203-0111

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A series of isomeric heterosubstituted 3-triarylmethylindoles were synthesized and their properties were evaluated. The activity of the synthesized compounds was found to depend on the mass of the side-chain substituent and on the position of the nitrogen atom in the heteroaromatic ring.