The debenzylation of 2, 6,8,12 tetraacetyl 4,10 dibenzyl 2,4,6,8,10,12 hexaazatetra cyclo[5.5.0.0 3,11 .0 5,9 ]dodecane by catalytic hydrogenolysis in a mixture of HСООH with other RCOOH (R = Me, Et, Pr i ) is accompanied by the N formylation of the liberated secondary amino groups. The alkaline hydrolysis of the obtained products makes it possible to remove the formyl groups with the retention of the acetyl groups.
In this paper, we studied the nitration of 2,4,6,8,10,12-hexaazaisowurtzitane acyl derivatives with mixed H 2 SO 4 /HNO 3 and HNO 3 /NH 4 NO 3 . The substitution of the nitro group for acyl residues of weaker acids took place most easily. The nitration of such amides in the mixed acid proceeded fairly good. In the case of using amides of formic and other stronger acids, the best results were achieved with HNO 3 /NH 4 NO 3 .
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.