Nanogels are highly recognized as adaptable drug delivery systems that significantly contribute to improving various therapies and diagnostic examinations for different human diseases. These three-dimensional, hydrophilic cross-linked polymers have the ability to absorb large amounts of water or biological fluids. Due to the growing demand for enhancing current therapies, nanogels have emerged as the next-generation drug delivery system. They effectively address the limitations of conventional drug therapy, such as poor stability, large particle size, and low drug loading efficiency. Nanogels find extensive use in the controlled delivery of therapeutic agents, reducing adverse drug effects and enabling lower therapeutic doses while maintaining enhanced efficacy and patient compliance. They are considered an innovative drug delivery system that highlights the shortcomings of traditional methods. This article covers several topics, including the involvement of nanogels in the nanomedicine sector, their advantages and limitations, ideal properties like biocompatibility, biodegradability, drug loading capacity, particle size, permeability, non-immunological response, and colloidal stability. Additionally, it provides information on nanogel classification, synthesis, drug release mechanisms, and various biological applications. The article also discusses barriers associated with brain targeting and the progress of nanogels as nanocarriers for delivering therapeutic agents to the central nervous system.
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Conventional delivery of antidiabetic drugs faces many problems like poor absorption, low bioavailability, and
drug degradation. Nanoemulsion is a unique drug technology which is very suitable for the delivery of antidiabetic drugs.
In recent years the flaws of delivering anti-hypoglycaemic drugs have been overcome by choosing nanoemulsion drug
technology. They are thermodynamically stable and also deliver the therapeutic agent for a longer duration. Generally,
Nanoemulsions are made up of either oil-in-water or water-in-oil and size of the droplets is from fifty to thousand
nanometer. Surfactants are critical substances which are added in the manufacturing of nanoemulsions. Only the
surfactants which are approved for human use can be utilized in the manufacturing of nanoemulsions. Generally, the
preparation of emulsions includes mixing of the aqueous phase and organic phase and using surfactant with proper
agitation. Nanoemulsions are used for antimicrobial drugs, and they are also used in the prophylaxis of cancer, diabetics.
Reduction in the droplet size may cause variation in the elastic and optical behaviour of nanoemulsions.
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