Data from 4081 vaginal deliveries (no caesarean sections) were analyzed retrospectively (IBM 730/158) with regard to duration of second and "final stage" of labour and fetal outcome (acid-base balance and apgar scores). The average duration of the two periods amounted to 22.8+/-29.6 and 9.9+/-7.8 min. Mean pH (UA) was 7.268+/-0.084 and the acidotic risk (pH less than 7.20, pH less than 7.10) 13.4 and 1.6% respectively. The distribution of the Apgar-scores after 1 min was assessed: 0-3: 1.7%, 4-6: 5.4%, 7-10: 92.9%. The dependance of the time variables from parity was studied. Two samples (N1=1755, N2=1098) of uncomplicated term pregnancies were chosen according to 7 clinical selection criteria differing only in the presence of cord entanglements at birth. The association between the two time variables and parameters of the fetal acid-base balance in cord blood was evaluated using rank correlation- and polynomial regression analysis. Highly significant correlations (tau) were found between the variable time and actual pH in blood of the umbilical artery and vein as well as pCO2, BEECF and HbO2 in the umbilical vein. The association however is not very close and thus clinically not of great importance. The deltapH (UA & UV) pro 60 min of second (and "final") stage of labour was computed and amounted to -0.024 (-0.087) in blood of the umbilical artery and -0.036 (-0.115) in blood of the umbilical vein and -0.017 (-0.062) (UA) and -0.032 (-0.120) units (UV) in the sample with and without apparent cord entanglements at birth respectively. The response of fetal acid-base balance to cord compression during second stage of labour was assesses: The acidotic risk (pH less 7.2) was doubled: 14.5% (7.7%) and AV-differences of all variables were "opened" if cordcoilings were observed. Apgar scores were not significantly different. Moreover, the association between AV-differences of each parameter and the variable time was studied: it became evident that with passage of time AV-difference is "closed" (-0.052 AV DpH/60 min "final stage" of labour, N=1098) indicating time related impairment of placental function. From these observations and data of the literature the conclusion is drawn that second stage of labour should not exceed 45 min in any patient. Furthermore it is concluded that in cases without signs of impending fetal distress it seems to be possible to wait more than 20 (Multipara) or 30 min (Primipara) duration of "final stage" without increased risk of fetal peril measured in terms of acidemia and clinical depression. This is valid only in term pregnancies with the possibility of continuous monitoring of FHR, in cases with normal uterine activity, uneventful course of first stage of labour and cooperative, vigorous patients. The indications for termination of delivery by vaginal operations in cases without impending fetal distress are discussed.
Quantitative registration of fetal heart rate phenomena during delivery can be accomplished successfully by means of a score. The score correlates highly significantly with the actual pH value (UA) and the Apgar score (1 min). It is suitable both for offline and online analysis of intrapartal CTGs, and offers the prospect of quantitative fetal online monitoring.
ZusammenfassungHintergrund: Von neonatologischer Seite gibt es klare Hinweise, dass der Basenexzess (BE, mmol/l) im Kapillar-bzw. Nabelarterien (NA)-Blut besondere diagnostische und prognostische Aussagekraft hat. In seine Berechnung gehen die Hämoglobin (Hb)-Konzentration (g%), die aktuelle Sauerstoffsättigung (%) des Blutes und die Verteilung der Flüssigkeitskompartimente ein. Bisher wurden diese drei Messgröûen, die sich beim Feten teilweise deutlich von jenen des Erwachsenen unterscheiden, in den Blutgasanalysatoren kaum berücksichtigt. In der vorliegenden Studie sollte daher untersucht und verifiziert werden, welcher BE den Verhältnissen beim Feten/Neugeborenen am besten gerecht wird. Methodik: Aus einem nach klinischen Kriterien ausgewählten ¹Normalkollektivª von 7701 termingerecht, auf vaginalem Weg geborenen Einlingen, bei denen ein kompletter Blutgasstatus im NA-und NV-Blut vorlag, und zusätzlich auch die Hb-Werte bestimmt worden waren, wurde der reguläre BE (¹ak-tueller Basenexzessª nach RADIOMETER), der auf die reale Sauerstoffsättigung korrigierte Basenexzess (BE oxy ) und der Basenexzess im extrazellulären Raum des Feten (BE ecff , ¹standarti-sierte BEª, RADIOMETER) nach den bekannten mathematischen Beziehungen berechnet. Zusätzlich wurde den fetalen Verhält-nissen dadurch Rechnung getragen, dass drei verschiedene O 2 -Bindungskurven für HbF (Zander et al., Hellegers und Schruefer, Severinghaus und Ruiz) zur Anwendung kamen. Die unterschiedlichen BE-Werte wurden zur Verifikation ihrer Aussagekraft mit dem Apgar nach 1 Min., der Summe aus Apgar-Zahl nach 1 und nach 5 Min. und zusätzlich ± in einem Kollektiv von 342 Feten ± mit den elektronisch quantifizierten (CTG-Score) Herzfrequenzphänomenen, analysiert jeweils 30 Min. vor der Abstract Background: There are convincing data from neonatal studies that the base excess (BE, mmol/L) measured in capillary or cord blood offers special diagnostic and prognostic power in the newborn compromised by hypoxia. For computation of BE the hemoglobin concentration (Hb, %), the oxygen saturation (%) and the distribution of the fetal fluid compartments are necessary. Until now these three factors, which differ in the fetus when compared with adults, have not been taken into account using automatic blood gas equipment. This study therefore attempts to analyse and verify which BE will offer the best fit with the outcome conditions in the newborn. Methods: Using a cohort of 7701 singletons delivered at term by the vaginal route in whom a blood gas analysis in cord blood together with Hb measurements were available and plausible, three BE values were computed: the ordinary BE (actual BE, according to Radiometer determinations), the BE corrected to the real oxygen saturation (BE,oxy) and the BE in the extracellular fluid compartment of the fetus (BE,ecff) using the algorithms of O. Siggaard-Andersen. Moreover, three different oxygen saturation curves for fetal Hb (HbF) were applied, namely those of Zander et al., Hellegers and Schruefer and Ruiz et al. (Severinghaus). The...
All vaginal deliveries of the Department of Obstetrics and Gynecology of the University Basel (N = 4081) during the year 74/73 and of the University Tübingen (N = 3249) 75/74 were analysed using an IBM-system 370/135 Only alive singletons beyond the 28th week of gestation were analysed. Clinical management was quite different in the two departments; the incidence of vaginal operations (Basal 11.2%, Tübingen 12.6%), however, as well as the distribution of pH-values and Apgar-scores after 1 min were quite similar. Basel: Acidotic risk (i.e. pHUA less than 7.200) 13.5%, severe acidotic risk (i.e. pHUA less than 7.100) 1.55%, low Apgar-scores (1--3) 0.7%. Tübingen: :12.3%, 2.11%, 1.6%. 3.5% of all parturients (Basel) had duration of second stage of labour with active maternal pressure support lasting more than 30 min. In two highly selected samples differing only with regard to the occurrence of cord-entanglements at birth (N1 = 1755, N2 = 1098) the association (rank correlation method according to Kendall) between the parameters of the fetal acid-base balance and the duration of second stage of labour as well as duration of the period with "active bearing down" was studied. Without cord encirclements pH in the umbilical artery fall --0.087 and in the umbilical vein --0.115 units and with cord complications the values amounted to --0.062 (UA) and --0.120 (UV) respectively pro 60 min duration of second stage with "bearing down efforts". Analogous computations for pCO2, pO2 and HbO2 are presented. Apgar-scores in these samples showed a very loose connection with the time variables. From these data the conclusion is drawn that the indication to perform vaginal operations for termination of delivery should not primarily be governed by the factor time but rather by the whole obstetrical situation i.e. the possible fetal risk of the intervention. This holds only if maternal welfare is established and fetal well being is monitored continuously.
A severe amniotic infection syndrome with a septic shock and a consumption coagulopathy is reported after an amniocentesis in second trimester. In literature, the risk of an amnionitis after amniocentesis amounts to 0.1%-0.4% and the risk of a severe maternal infection reaches 0.03%-0.19%. The available data show, that the clinical symptoms (rise in temperature, signs of septic shock) start 24-36 hours after the punction. The earlier treatment (evacuation of the uterus or - if necessary - hysterectomy) is accomplished, the more favourable will be the course of the disease with respect to septic shock and DIC. Determination of germs in each amniotic fluid seems to be of prognostic value; thus treatment can be started before infection becomes detrimental for the mother.
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