Background. The problem of pathology of the affective sphere, especially anxiety and depressive disorders, at the present stage of development of society is especially relevant among general medical problems. In recent years, there has also been a pathomorphosis of mental disorders in various somatic and endocrine diseases. A link between thyroid disease and mental disorders, including autoimmune thyroiditis, has been found. Further research on this issue is important. The purpose of this study was to investigate the presence of mental disorders in women with subclinical hypothyroidism and euthyroidism on the background of autoimmune thyroiditis. Materials and methods. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS) in 176 women of reproductive age (18 to 44 years) with subclinical hypothyroidism and euthyroidism with autoimmune thyroiditis compared with healthy women. The examination was conducted before the start of therapy for the underlying disease. Results. It was found that out of the 176 women surveyed, 37.5 % of them had anxiety syndrome, 13.6 % had depression, 10.8 % of women had comorbid anxiety disorder and depression, and 38.1 % of those surveyed had normal results. The group of women with autoimmune thyroiditis and subclinical hypothyroidism was dominated by clinically severe anxiety (40.9 %) and depression (15.1 %), the percentage of detected subclinical anxiety and depression was 7.6 % and 7.6 %, respectively, while the group of women with autoimmune thyroiditis and euthyroidism was dominated by subclinically expressed anxiety (37.1 %) and depression (8.6 %), and the percentage of clinically expressed anxiety and depression was 5.7 % and 1.4 %, respectively. Conclusions. Anxiety-depressive syndrome is 3.5 times more common in patients with thyroid diseases than in healthy women. There is a direct correlation of weak strength between the level of TSH in women with subclinical hypothyroidism and the number of points scored during the survey on both scales HADS-depression (r = 0.12, p < 0.05) and HADS-anxiety (r = 0.14, p < 0.05). There was a direct correlation of weak strength between the level of TPO Ab and the number of points scored during the survey in both scales HADS-depression (r = 0.17, p < 0.05) and HADS-anxiety (r = 0.19, p < 0.05).
Background. In recent years, in Ukraine and other countries of the world, there has been an increase in the frequency of autoimmune thyropathies. A significant role in the pathogenesis of autoimmune thyroiditis (AIT) is played by cytokines whose production is increased significantly during immunopathological reactions. The purpose of study was to investigate the effect of the combined use of myo-inositol, vitamin D and selenium on the cytokine status of women with euthyroidism, subclinical hypothyroidism and overt hypothyroidism against the background of autoimmune thyroiditis. Materials and methods. One hundred and forty-seven women aged 18–43 with AIT and 30 women of the control group were under observation. Patients of first group (n = 74) received myo-inositol at a dose of 2000 mg/day, cholecalciferol 2000 IU/day, and selenium 100 μg/day additionally to the main treatment. Patients of the second group (n = 73) received only cholecalciferol at a dose of 2000 IU/day and selenium 100 μg/day additionally to the main treatment. The functional state of the thyroid gland was studied by determining the levels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine, antibodies to thyroid peroxidase (Ab-TPO) and antibodies to thyroglobulin (Ab-TG). The state of the systemic and local inflammatory process was evaluated according to parameters of tumor necrosis factor α, interleukins 6, 10, 17, and 23. Results. It should be noted all patients with AIT had changes in cytokine status, with some differences depending on the clinical variant of autoimmune thyroid disease. After three months of treatment of patients of the first group with myo-inositol at a dose of 2000 mg/day, cholecalciferol 2000 IU/day and selenium 100 μg/day, and patients of the second group only with cholecalciferol at a dose of 2000 IU/day and selenium at 100 μg /day, a significant difference was found between the indicators in both studied cohorts. Conclusions. The administration of myo-inositol, vitamin D, and selenium had a combination effect on the reduction of cytokine indicators, Ab-TPO and Ab-TG levels, which contributed to the compensation of the underlying disease.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.