Background. Relevant in pediatrics is the use of indicators of quality of life of children to personify the treatment process, monitoring the course of the disease. In recent years, there has been increasing research on the role of vitamin D and calcium in the human body. The study was aimed to assess the quality of life of infants and to establish the possibility of medical correction of the main indicators of quality of life under the influence of the combined use of vitamin D and calcium. Materials and methods. We observed 30 clinically healthy infants who received 2.5 ml of vitamin D and calcium 3 times a day for 2 months. We have created our questionnaire on the quality of life of infants. Methods of variation statistics are used. Results. Based on the correlation analysis in infants before treatment, there was found a positive relationship between quality of life and the state of biological resistance (r = +0.51; p < 0.05); natural feeding (r = +0.56; p < 0.05); symptoms of functional gastrointestinal disorders (r = +0.58; p < 0.05); parameters of emotional status (r = +0.62; p < 0.05); signs of autonomic dysfunction syndrome (r = +0.63; p < 0.05); neuropsychological development (r = +0.65; p < 0.05); features of adaptability (r = +0.66; p < 0.05). The results of the treatment with vitamin D and calcium in the study of the correlation diagram of the relationship between quality of life and the established indicators of the development of infants demonstrated no correlation between the quality of life and symptoms of functional gastrointestinal disorders and symptoms of autonomic dysfunction. After treatment, there was a decrease in the strength of the correlation between the quality of life of infants and the parameters of emotional status (r = +0.36; p < 0.05); indicators of neuropsychological development (r = +0.35; p < 0.05), and ability to adapt (r = +0.44; p < 0.05). Conclusions. The сombined use of vitamin D and calcium in the recommended dose of 2.5 ml 3 times a day for 2 months is characterized by a high safety profile, improves the quality of life of a child, and can be recommended for infants.
The scientific review presents the process of regulation of miRNA content — the association of miRNA expression activity with circadian rhythms of organism functioning and the dependence on the presence of single nucleotide gene polymorphisms. To write the article, information was searched using databases Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The Cochrane Library, CyberLeninka. The article presents the characteristics of the molecular architecture of circadian clocks of mammals, which are due to the action of day and night, light and darkness. It is stated that the violation of circadian rhythms of the organism is associated with the development of obesity, diabetes, depression, cardiovascular pathology, and tumors. It is also known that the violation of the circadian rhythm of liver function leads to the development of metabolic disorders and, in particular, the emergence of non-alcoholic fatty liver disease, diabetes, and obesity. It is emphasized that microRNAs are factors that determine the functioning of circadian rhythm mechanisms, and the expression of some of them is highly dependent on the time of day. The article shows that to date, more than 240 single-nucleotide polymorphisms of genes and rare mutations in pri-, pre- and mature miRNA sequences have been identified. It is known that single nucleotide polymorphisms of genes of the first group (pri- and pre-microRNAs) interfere with the normal process of maturation of microRNAs. Single-nucleotide polymorphisms of genes of the second group (“seed” region) lead to disruption of the interaction of microRNAs with target mRNAs. An association between microRNA genetic polymorphisms and various human diseases, including diseases of the hepatobiliary system, has been established. Thus, the activity of miRNA expression determines the functioning of the mechanisms of the circadian rhythm of the mammalian organism, and the expression of some of them is highly dependent on the time of day. The normal process of maturation of miRNAs is hindered by single nucleotide polymorphisms of genes of the first group (pri- and pre-miRNAs). Single nucleotide polymorphisms of genes of the second group lead to disruption of interaction of miRNA with mRNA targets. Circadian rhythm disorders and genetic microRNA polymorphisms are associated with the development of various pathological conditions and human diseases, including diseases of the hepatobiliary system.
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