evidence-based cancer care in the United States: the *Case numbers represent the total volume from 2004 to 2015. Data are presented as number (%). The percentages represent valid percentages, excluding patients with missing information.
for the treatment of renovascular hypertension in such patients. Methods A retrospective search was conducted of a local database of all patients with confirmed Alagille syndrome and renovascular hypertension treated with PTA. Data for each patient was then collected from medical and electronic records. Results Four patients were identified with Alagille syndrome and renovascular hypertension. In total, 8 PTA procedures were carried out including one for management of renal artery aneurysm. There were no intra or peri-operative complications including significant bleeding. In addition, two patients needed unilateral nephrectomies for non-functioning kidneys. 75% of patients had improvement in blood pressure at last follow up. There was a peri-procedural rise in serum creatinine of 10-73% in 57% of PTA procedures, the majority of which normalised at last follow up. Conclusions In a tertiary paediatric renovascular centre, PTA can be safely performed in patients with Alagille syndrome. Improvement in blood pressure was observed in 75% of cases. Furthermore, this study confirms that patients with Alagille syndrome and renovascular hypertension might need more than one PTA and these should be done in a specialist centre with experience in this patient cohort.
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