Eupatoriopicrin (EUP), the principal sesquiterpene lactone from Eupatorium cannabinum L., exhibits cytostatic activity in vitro as well as in vivo (1-3). After administration of EUP to tumour-bearing mice, reduction of glutathione (GSH) levels has been found in liver and tumour tissue (4). Moreover, it was demonstrated that the intensity of cytostatic action, in vitro and in vivo, depends on the GSH status of the cells: reduction of intracellular GSH by means of BSO, a specific inhibitor of GSH synthesis, enhanced the cytostatic effect of EUP (5).GSH protects the cells against xenobiotics by electrophilic thioether conjugation or by scavenging induced reactive oxy-
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.