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Synthesis and QSAR Studies of Pyrimido[4,5-d]pyrimidine-2,5-dione Derivatives as Potential Antimicrobial Agents. -A number of pyrimidopyrimidinedione derivatives (V) (11 examples) are synthesized, which exhibit excellent in vitro antibacterial and antifungal profile. -(SHARMA*, P.; RANE, N.; GURRAM, V. K.; Bioorg.

Organo-phosphorus compounds S 0080Synthesis and Evaluation of Quantitative Structure-Activity Relationship of 10-Methyl-6-oxo-5-arylazo-6,7-dihydro-5H-[1,3]azaphospholo[1,5-d][1,4]benzodiazepin-2-phospha-3-ethoxycarbonyl-1-phosphorus Dichlorides. -A five-membered phosphole ring system is linked up with a benzodiazepine nucleus in order to frame the novel molecular architecture of annulated heterophospholobenzodiazepines. The role of this nucleus against the problem of multidrug-resistant pathogens is investigated. The tricyclic system (X) shows remarkable in vitro inhibitory activity on the growth of tested bacterial and fungal strains. Quantitative structure-activity relationship investigations indicate that the molecular refractivity correlates significantly with the antimicrobial activity. -(KUMAR*, A.; SHARMA, P.; GURRAM, V. K.; RANE, N.; Bioorg. Med. Chem. Lett. 16 (2006) 9, 2484-2491; Sch. Chem. Sci., Devi Ahilya Univ., Indore 452 017, India; Eng.) -H. Hoennerscheid 31-159