Most studies have considered the negative influence of obesity on fertility in both genders. In the present study, we assessed mitochondrial activity expressed as the mitochondrial potential index (MPI) in cumulus cells from obese women and women with a normal body mass index (BMI) during assisted reproductive therapy. The results revealed a significant reduction of MPI with increased body mass. The lower MPI levels in cumulus cells from obese women may reflect mitochondrial dysfunction caused by oxidative stress, which can affect the cumulus-oocyte complex and have an impact on oocyte development.
when compared to men with normal BMI. CPR achieved through ART were reduced in OW men (OR 0.9% [95% CI 0.64, 1.28], P¼0.56, I 2 ¼ 75%) and OB men (OR 0.77% [95% CI 0.59, 1.01], P¼0.06, I 2 ¼ 33%). LBR achieved through ART were reduced in OW men (OR 0.92% [95% CI 0.72, 1.18], P¼0.51, I 2 ¼ 65%) and OB men (OR 0.81% [95% CI 0.59, 1.11], P¼0.19, I 2 ¼ 67%). Sub group analyses showed that the recent changes in the 2010 WHO reference values for semen parameters had significant negative effects only on TPMSC in OW men and semen volume, count, morphology and TPMSC in OB men.CONCLUSIONS: Pooled results from evaluated studies suggest that BMI negatively affects semen parameters in infertile men. The full clinical implications of the 2010 WHO criteria on the association between BMI and human semen quality and fecundity rates deserve further investigation.
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