The article has analyzed the world experience and main trends in the preparation of cadaveric skin for use in the treatment of patients with wounds of various etiologies. The history of the question is described from the first attempts of transplantation of the native skin to the creation of specialized banks of allogenic decellularized tissue grafts. Presented are the modern approaches of donor material conservation, specifically, to the principle and topical question: whether the viability of the cells should be preserved in the graft, or it is more efficient to transplant the skin devoid of cellular elements. The advantages and disadvantages of lyophilized grafts have been described, namely the possibility of longterm storage, but loss of elasticity, after rehydration. The methods of cryoconservation of cutaneous allografts, their properties, and acceptable methods of sterilization have been discussed. A perspective technology of graft decellularization has been assessed and the methodologies of their manufacturing have briefly been presented.
The paper presents the results of a multicenter postmarketing clinical laboratory study of Eplan ointment and eplan solution for the topical treatment of skin and soft tissue infections in outpatient, inpatient, and field settings. The results of the study in 793 patients with skin and soft tissue infections of different locations and genesis demonstrate the high clinical efficacy of the medicaments along with their easy-to-use formulation and economic availability.
INTRODUCTION Based on the Ministry of Emergency Situations data megapolises note an annual increase of the emergency situations (ES). The increase of an urban population in Russia up to 73% results in considerable human victims in big cities due to thermal injuries among others.THE AIM of the present research is to analyze the structure of ES victims and the efficiency of the organization of a medical care for victims with thermal injuries in Moscow in 2016–2018.MATERIAl AND METHODS We have held a retrospective analysis of 113 cases of patients of a Burn Center of Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department, and have studies the data of an automated informational analytical system named “Emergency Medicine” for 2016 2018.RESUlTS For an absolute number of victims, fires are on the third place among different emergencies in Moscow, but on the prehospitalization stage, the biggest number of deaths are registered (38,2%). The number of patients with thermal injuries reaches 31% among all the patients in hospitals. We note a multifactor and a combined character of injuries characterized by a high mortality rate (9,8%).CONClUSION A present system of medical help for patients with thermal injuries, from the moment of ES fact to the hospitalization to multidisciplinary treatmentandprophylactic organizations having an experience of specialized medical services, is a reliable and effective element of the health system.
Introduction Inhalation injury (ini) makes burn disease more severe. However, it remains unexplored what is the minimum area of the burn that can significantly aggravate of the course of ini.The objective was to compare the incidence of acute respiratory failure (arf), pneumonia, and mortality between patients with ini and ini with superficial skin burns up to 3% total body surface area (tbsa).Material and methods 125 patients with ini and i–ii degree skin burns up to 3% tbsa were allocated into 4 groups: ini without skin burns, ini with burns up to 1% tbsa, up to 2%, and up to 3% tbsa.Results In the group with ini and skin burns up to 2%, the number of arf, pneumonia cases, and deaths did not statistically significantly differ from the ini group, however in group of ini and burns of more than 2% tbsa, there were more of those complications.Conclusion Skin burns of i–ii degree over 2% tbsa increase the incidence of acute respiratory failure, pneumonia, and death in patients with ini.
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