Introduction: Prelabour rupture of membranes (PROM) is defined as the membrane rupture at term without spontaneous uterine contractions. In 10% of term pregnancies and 30-40% preterm pregnancies, foetal membranes fail to maintain their structural integrity resulting in their prelabour rupture. Study aimed to compare the safety and efficacy of misoprostol by two different route's of administration i.e., oral and buccal in women with PROM at term. Material and Methods: 100 patients with PROM were divided into oral and buccal group equally. Both the groups received 25µg of misoprostol every 4 th hourly, either orally with water or it was held in the cheek in the buccal group, maximum upto 6 doses in either group. Result: The prevalence of PROM in the present study was 7%. All demographic varaiables are insignificant in both groups. oxytocin augmentation required was found to be statistically significant in both groups. Mean induction delivery interval was shorter in buccal group (13.966±4.68) compared to oral group(17.126±5.10) which was statistically significant. The change in the pre-induction Bishop score after 12 hours was slightly higher in the buccal group compared to oral group which was statistically. Tachysystole was higher in buccal group (8%) compared to oral group(2%), There were no cases of still births and neonatal deaths in both groups. No significant differences were found in hospital stay and NICU admissions in both the groups. Conclusion: Buccal misoprostol is more efficacious than oral misoprostol. Women who received buccal misoprostol experienced shorter induction to delivery interval, required fewer doses of misoprostol and required oxytocin augmentation less frequently than those who received oral misoprostol.
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