Abstract. Thirty heroin addicts and thirty non-addicts fmm the Saffna Municipality and suburbs were chosen randomly. All the selected subjects were mates and the mean ages of addicts and non-addicts were 33.4 (+ 4.4 SD) years and 30.9 (2 3.9) years respectively. Of the addicts 70% took heroin by smoking. Addicts had taken 187.5 (+ 89.4) mg heroin, four times (+ 0.88 ) a day and had been using this drug for at least 3.2 (+ 2.0) years. There were no sipificant difference behveen body weights and blood pressures of addicts and non-addicts. A modified glucose tolerance test showed that the mean blood glucose levels were significantly increased in the addicts. Mean serum free fatty acid levels and the mean ratb of s e a i n total cholesterol to HDL cholesterol were significantly higher in addicts than non-addicts? Likewise the serum aspartate transaminase (AsT) and serum alanine tmnsaminase (ALT) levels of addicts were significantly higher than in the non-addicts.
Abstrad: Beedi smoking is common in Sri Lanka and hence a study was undertaken to determine the effects of beedi smoking on selected clinical biochemistry parameters. 7CRirt.y non-alcoholic beedi smokers and thirty nonalcoholic non-smokers from the same socio-economic status were selected from the Jaffna Munici~alitv. The mean a w s of beedi smokers and non-smokers were " -45 ( rf: 6.4) and 44( rf: 7 . 3 )~ respectively. Mean serum ascorbic acid and protein levels were significantly decreased in beedi smokers. Although plasnla fibrinogen level in beedi smokers was within normal range, it was significantly elevated compared to non-smokers. Beedi smokers showed a significant elevation in serum bilirubin level. Serum alanine transaminase (ALT) in beedi smokers was significantly elevated while aspartate transaminase (AST) showed no significant change. Glucose tolerance was s~gnificantly decreased in smokers. Furthermore urinary excretion of creatine was significantly increased while the urine volume and creatinine excretion were not significantly altered in beedi smokers.
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