Зв'язок роботи з науковими програмами, планами, темами. Дослідження проводилися відповідно до теми науково-дослідної роботи «Оптимізація діагностики і профілактики хронізації мікробно-запальних захворювань сечовивідної системи та прогресування нефропатій у дітей керуванням
Magnesium deficiency is observed in many physiological and pathological conditions (imbalanced diet, diabetes, cardiovascular diseases, etc.). Magnesium ions are of great importance in the realization of immune reactions, inflammation, nervous and muscular excitability. The deficiency of magnesium is one of the main causes of stress and low stress resistance. Reduction of magnesium content destabilizes the systems responsible for adaptation and facilitates its sensitization, what determines anxiety and high stress level of patients. Understanding the mechanisms of magnesium involvement in the pathogenesis of stress and the development of a stress reaction will allow a family physician to assess the clinical manifestations of magnesium deficiency early in order to provide proper therapy for its correction.
The article considers the drug treatment of the patients with arterial hypertension (AH) and coronary artery disease (CAD). Arterial hypertension is one of the main modifying risk factors of stroke, cardiovascular failure and CAD. Arterial hypertension and CAD are generally comorbid conditions having common pathogenic mechanisms. The great social impact of these diseases and their complications predetermine the search for new ways of improving treatment of patients with above mentioned combined pathology. Numerous clinical studies confirmed the advisability of dihydropiridine calcium channel blockers (CCB) as an effective therapy of hypertension associated with CAD. For example of CCB, in particular amlodipine, the efficiency CCB in hypertensive patients at high cardiovascular risk is demonstrated. Amlodipine is effective as both antihypertensive and antianginal agent with antiatherosclerotic and cardioprotective properties. Besides amlodipine has a high level of safety which explains its active use in clinical practice, in particular, for treating patients with hypertension associated with CAD.
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