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Novel derivatives of quinolizidine alkaloid (-)-cytisine were synthesized. Main ADME properties, cytotoxicity against HEK293 cell line and activity against viruses of influenza A/California/7/09(H1N1)pdm09 virus (IAV) and human parainfluenza virus type 3 (HPIV3) were evaluated. It was shown, that 9-carboxamides of methylcytisine (with phenyl and allyl urea's fragments) are most active compounds against IAV probably due to predicted in silico peculiarity of their interactions with the 4R7B active site of IAV neuraminidase. Indexes of selectivity (SI) calculated as ratio of CC 50 /IC 50 of these ureas are 47 and 59 correspondingly (SI of ribavirin is 67, and SI of rimantadin is 5). It was also found, that derivatives obtained from allyl isocyanate and (-)cytisine or 9,11-dibromocytisine are able to inhibit a reproduction of HPIV3 with SI = 58 and 95 (SI of ribavirin is 192 in this case). Moreover, last compound -(1R,5R)- N-allyl-9,11-dibromo-8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocine-3(4H)-carboxamide with two bromine atom in 2-pyridone core of starting (-)-cytisine molecule, demonstrated high activity against HPIV3 (SI=95) and moderate activity against IAV (SI=16).

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