The effects of beta‐carotene, vitamin E and a pharmaceutical complex of natural anti‐oxidants (OXY‐GARD) on abnormally high ornithine decarboxylase (ODC) activity in antral gastric mucosa of patients with atrophic gastritis (AG), accompanied by intestinal metaplasia (IM), were studied in a randomized placebo‐controlled clinical trial. In cases with H. pylori infection, preliminary eradication of this bacterium was carried out utilizing a standard chemotherapeutic schedule (de nol+metronidazole+oxytetracycline). Efficient eradication of H. pylori resulted in an ODC activity decrease of 16%, on average. It was shown that supplementation with beta‐carotene, at a daily dose of 20 mg, or with vitamin E, at a daily dose of 400 IU, produced decreases in ODC activity of 46% and 44%, respectively, by three months. Daily supplementation with 1 or 2 capsules of OXY‐GARD for three months resulted in ODC activity decreases of 23% and 48%, respectively. Taking into account that abnormally high ODC activity is associated with a high oncogenic potential and plays a specific role in tumor promotion, it is reasonable to suggest that beta‐carotene, vitamin E and OXY‐GARD act in atrophic or premalignant gastric mucosa as anti‐promoters.
Preliminary data indicate that prolonged administration of these nutritional supplements, e.g. beta‐carotene for one year, to IM patients produces the maximum decrease in ODC activity at three months. We found that this decrease was accompanied by a delayed partial regression of IM in nine of 18 patients (response rate 50%, 95% confidence interval 26–74%). A study on the effects of long‐term vitamin E or OXY‐GARD supplementation on IM regression is currently in progress. (Dig Endosc 1996 ; 8 : 184–191)
Background. Clear-cell renal-cell carcinoma (CCRCC) is the most common histological type of cancer of this localization. Changes in 16 genes were identified as significant in carcinogenesis of CCRCC. After VHL suppressor gene, PBRM1 gene is the second by frequency of genetic abnormalities in CCRCC and it is mutated in 40-50 % cases of CCRCC.
The study objective is to analyze the effect of abnormalities in PBRM1 protein expression on survival of patients with CCRCC.Materials and methods. The study included 137 patients with newly diagnosed and histologically confirmed CCRCC. For all study participant, detailed medical history and questionnaire data were acquired. Prior to treatment, blood samples and tumor tissue removed during surgery were obtained from all patients. All patients are annually followed up for current information on their life status, disease dynamics, treatment.
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