In a preliminary investigation certain pharmacognostic, physicochemical and pharmacological characteristics of Crofon penduliflorus were studied to know whether or not the plant merits any serious recognition in scientific pharmacotherapeutics. Extracts of seeds, leaves, stem-bark and root prepared in several solvents were subjected to physicochemical and pharmacological investigations.The extracts showed positive reactions primarily towards tests for alkaloids, sterols and/or terpenoids and for flavonoids. Thin layer chromatography (TLC) of extracts revealed the presence of two major constituents with low and high Rf values. The petroleum ether and alkaline chloroform extracts in particular exerted cholinomimetic effects on isolated guinea pig ileum, rat uterus and frog rectus abdominis muscle. The seed extracts generally exhibited the most pronounced and prolonged cholinomimetic effects. Pharmaceutical Biology Downloaded from informahealthcare.com by McMaster University on 11/26/14 For personal use only. Pharmaceutical Biology Downloaded from informahealthcare.com by McMaster University on 11/26/14For personal use only.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.