Background: Corona Virus Deases 2019 is an infectious disease caused by the corona virus. COVID-19 is currently a challenge for diabetes patients. Diabetes mellitus predisposes to a very severe disease course and increases the risk of death from COVID-19. This study aims to estimate the average magnitude of the effect of diabetes mellitus comorbidity on the risk of death of COVID-19 patients. Subjects and Method: This was a systematic review and meta-analysis. This research was conducted using secondary data that will be conducted by searching and selecting data from the results of clinical trials conducted around the world. Search for articles through systematic and comprehensive databases from Pubmed, Google Scholar, Springer Link. The analysis in this study was carried out using the Review Manager 5.3 software. The results of the analysis are the effect size, heterogeneity and then the study model. Variations between studies are used to determine the analysis model which is divided into two models, namely the fixed effect model (FEM) and the random effect model (REM). Results: Based on the results of the analysis, there was high heterogeneity between experiments (I 2 = 85%; p= 0.04), so that the Random Effects Model (REM) was used. COVID-19 patients with comorbid diabetes mellitus were 2.17 times more likely to die than patients without comorbid diabetes mellitus (aOR 2.17; 95% CI 1.04 to 4.54). Conclusion: Diabetes mellitus co-morbidity increases 2.17 times the risk of death in COVID-19 patients compared to patients without diabetes mellitus comorbidity.
Background: Previous studies reported that adults with certain comorbid conditions are at increased risk for severe illness of Covid-19. The purpose of this meta-analysis study was to assess the effect of diabetes mellitus comorbidity on the severity in patients with Covid-19 infection. Subjects and Method: Meta-analysis and systematic review was conducted by collecting articles from Pubmed, Google Scholar, and Springer Link online databases, from 2019 to 2020. Keywords used “COVID-19 and comorbidity”, “COVID-19 and severity and diabetes”, “comorbidity or severity or diabetes or adjusted odd ratio”. The inclusion criteria were full text, using English and Indonesian language, using observational study, primary study in hospital. The study population (P) was COVID-19 patients. Intervention (I) was diabetes mellitus with comparison (C) without diabetes mellitus. The study outcome (O) was risk of severity. The data were analyzed using random effect model in Revman 5.3. Results: There were 6 studies from South Korea, United States, and China. This study had high heterogeneity (I2= 65%, p= 0.01). DM comorbidity increased the risk of severity 2.74 times in patients with comorbidity than those without DM comorbidity (aOR=2.74; 95% CI= 1.37 to 5.48; p=0.004). Conclusion: Diabetes mellitus comorbidity increases the risk of severity in patients with COVID-19. Keywords: COVID-19, severity, diabetes mellitus, comorbidity Correspondence: Utin Ilma Agni Kun’ain. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: utinilmaagni8p@gmail.com Mobile: +628111044542. DOI: https://doi.org/10.26911/the7thicph.05.57
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.