Ap alladium-catalyzed coupling between aryl halides and monocyclopropanated pyrroles or furans has been developed, leading to valuable six-membered N-and Oheterocycles.A st he key step,as elective cleavage of the nonactivated endocyclic CÀCb ond of the 2-heterobicyclo-[3.1.0]hexane framework is achieved. The developed method offers access to highly functionalized piperidines,p yridines, and pyrans that are challenging to access by traditional methods.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.
We have measured the yields of strand break formation and biological inactivation as a function of OH scavenger concentration for 60Co gamma-irradiated pBR322 plasmid and M13mp9 RF phage DNA. The yields of single-strand breaks (ssbs), double-strand breaks formed proportionally to dose (alpha dsbs), and lethal damage (LD) decrease with increasing scavenging capacity sigma, their ratios remaining approximately constant up to sigma approximately 10(8) s-1. On a double-logarithmic plot the yields decrease linearly with sigma in parallel lines. At higher scavenging capacities, the yields, while still decreasing, level off to a different extent. Our results for the yields of ssbs and alpha dsbs confirm those of Krisch et al. (1991) using SV40 DNA. The data were analysed assuming that DNA damage is brought about by OH radicals, and a non-scavengeable portion arising from the direct radiation effect. Using a model based on non-homogeneous scavenging kinetics, the dependence on scavenging capacity of the ssb yield could be quantitatively accounted for. From the scavenging dependence of the yield of dsbs which are formed quadratically with dose (beta dsbs) and which are the result of two independent ssbs within a critical distance h, a value of about 13 basepairs was obtained for h. The parallel decrease in the yield of ssbs and alpha dsbs with scavenging capacity was rationalized in terms of the Siddiqi-Bothe mechanism (Siddiqi and Bothe 1987). The efficiency of this mechanism was found to be approximately 0.01. From the analysis of the LD yields it was shown that up to sigma approximately 10(8) s-1, inactivation is predominantly due to single OH radicals which lead to LD with an efficiency of 0.12 per OH-induced ssb. At higher scavenging capacities, a non-scavengeable spur effect similar to the locally multiply damaged sites mechanism of Ward (1988) mainly contributes to LD.
Herein, we report a versatile approach
for the endocyclic ring
opening of bicyclic vinylcyclopropanes triggered by Heck arylations.
The key step for this transformation is a β-C-elimination allowing
the ring expansion of cyclopropanated pyrroles, piperidines, furans,
as well as cyclopentadienes to grant access to the corresponding 1,2-dihydropyridines,
2H-pyrans, 2,3-dihydro-1H-azepines,
and 1,4-cyclohexadienes, respectively. Additionally, gem-disubstituted cyclopropanated furans showed unexpected behavior
by giving diastereoselectively asymmetrically substituted dienes.
Mechanistic studies and theoretical calculations point toward a facile
β-C-elimination with a concomitant shift of Pd along the cyclopropane
moiety, which can successfully compete with the usual termination
step of a Heck reaction via a syn-β-hydride elimination.
A new strategy for stereoselective preparation of all four isomers of β- and γ-hydroxy α-amino acids is presented. The developed procedure is based on enzymatic kinetic resolution and cyanate-to-isocyanate rearrangement as key steps. Stereocontrol is achieved by proper choice of the starting hydroxyacid, the course of kinetic resolution, and the stereospecific sigmatropic rearrangement step, which proceeds with full chirality transfer.
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