2005Multi-membered N-heterocycles R 0690 Asymmetric Synthesis of 1-Substituted Tetrahydro-3-benzoazepines. -A new asymmetric synthesis of substituted benzodiazepine (VII) via the key intermediate (II) is reported. The tricyclic ring system allows the diastereoselective alkylation to obtain benzyl derivative (V) with high diastereoselectivity (95:5). -(WIRT, U.; FROEHLICH, R.; WUENSCH*, B.; Tetrahedron: Asymmetry 16 (2005) 13, 2199-2202; Inst. Pharm. Med. Chem., Westfael. Wilhelms-Univ., D-48149 Muenster, Germany; Eng.) -Bartels 49-154
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