Two–dimensional (2D) metal–organic frameworks (MOFs) are fascinating photocatalytic materials because of their unique physical and catalytic properties. Herein, we report a new (E)–4–(3–carboxyacrylamido) benzoic acid [ABA–MA] ligand synthesized under facile conditions. This ABA–MA ligand is further utilized to synthesize a copper-based 2D MOF via the solvothermal process. The resulting 2D MOF is characterized for morphology and electronic structural analysis using advanced techniques, such as proton nuclear magnetic resonance, Fourier-transform infrared spectroscopy, ultraviolet–visible spectroscopy, and scanning electron microscopy. Furthermore, 2D MOF is employed as a photocatalyst for degrading organic dyes, demonstrating the degradation/reduction of methylene blue (MeBl) dye with excellent catalytic/photodegradation activity in the absence of any photosensitizer or cocatalyst. The apparent rate constant (kap) values for the catalytic degradation/reduction of MeBl on the Cu(II)–[ABA-MA] MOF are reported to be 0.0093 min−1, 0.0187 min−1, and 0.2539 min−1 under different conditions of sunlight and NaBH4. The kinetics and stability evaluations reveal the noteworthy photocatalytic potential of the Cu(II)–[ABA–MA] MOF for wastewater treatment. This work offers new insights into the fabrication of new MOFs for highly versatile photocatalytic applications.
Various formulations consisting of biomaterials zirconium imidazolate framework-8 (ZIF-8), choline acetate ([Ch][Ac]), and arginine hydrochloride (argHCl) are optimized to study the stability of antibody, Immunoglobulin G (IgG). We have performed several instrumentations including UV−visible spectroscopy, dynamic light scattering (DLS), circular dichroism (far UV CD), and atomic force microscopy (AFM) in the presence of all the formulations to investigate the conformational and colloidal stability of the antibodies. Alongside, the packing efficiency of all the formulations was also explored by storing IgG at 4 °C for 3 months. We have tried to investigate the interactions between biomaterials and antibodies with the motive of designing aggregation-resistant formulations. The overall stability of IgG was improved in the presence of [Ch][Ac]; however, ZIF-8 and argHCl cause relatively more aggregation, although the structure was retained in all the formulations. The key aspect of this study is that the presence of [Ch][Ac] increases ZIF-8@IgG's thermal stability and resistance to IgG-argHCl aggregation. All over, for the first time, with different experimental approaches, the impact of each biomaterial individually and in combination is explored to study their effect on the stability of antibodies. Thus, better efficient formulations can be designed for the storage/packaging of IgG-based drugs which ultimately will have more applicability in pharmaceuticals.
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