Objective: Drug abuse and drug addiction cases have been increased immensely in last few decades in Pakistan. This study was conducted to assess the frequency of cutaneous manifestations in drug abuse patients. Study Design: Cross Sectional study. Settings: Dermatology Department of a DHQ Teaching Hospital/Sahiwal Medical College, Sahiwal and Central Jail Hospital, Sahiwal. Period: November 2019 to June 2020. Material & Methods: 50 patients with drug abuse irrespective of age and gender were selected. Skin manifestations based on history and examination recorded on predesigned proforma. Laboratory investigations and skin biopsies were performed to confirm diagnoses in doubtful cases. Results: A total of 50 male patients with age above 16 years were enrolled. Single drug addiction was noticed in 62% (n=31) and polydrug abuse was observed in 38% (n=19). Regarding mode of drug intake, single and multiple modes of drug administration were seen in equal number 50% (n=25) each. Major bulk of skin manifestations were chronic including skin scars 66% (n=33), xerosis 60% (n=30), hyperpigmentation 58% (n=29), oral mucosal changes 94% (n=47) and facial skin changes 60% (n=30). Acute along with chronic skin changes were observed in 30% (n=15) mainly including injection marks 30% (n=15), vascular changes 12% (n=6) and infections 8% (n=4). Conclusion: Skin scars, xerosis, hyperpigmentation and oral mucosal changes are the common skin changes observed among drug abusers. Thus, physicians need to be aware of skin signs of drug abuse for timely recognition of substance abuse disorders and effective management.

Background and Objecive: Fine needle aspiration cytology of the focal liver lesions in conjunction with cell block formation offers a convenient, less invasive and better diagnostic tool. This study was carried out to determine the diagnostic accuracy of fine-needle aspiration cytology in comparison with cell block from the aspirates taken from focal liver masses. Methods: This cross-sectional study was carried out over 13 months inthe Department of Pathology, Allama Iqbal Medical College Lahore, Pakistan in collaboration with the Department of Radiology, Jinnah Hospital Lahore, Pakistan. A total of 60 ultrasound-guided fine-needle aspiration cytological smears along with cell block material were collected from patients with focal liver lesions.Features of malignancy were noted on the fine-needle aspiration of liver lesions followed by cell blocks.Results: Cytological diagnosis based on FNAC in 59 cases was benign, out of which 39 (66.0%) were amoebic liver abscess, 14 (23.7%) were pyogenic liver abscess, 2 (3.4%) were tuberculous hepatic abscess supported by the same findings on cell block. One case (1.7%) was diagnosed as malignant on FNAC, later on, confirmed by the cell block. Four (6.7%) cases on FNAC were reported as benign lesions which were later on diagnosed as hepatocellular carcinoma on the cell block. Taking cell block as gold standard, the sensitivity, specificity, positive predictive value negative predictive value and diagnostic accuracy of FNAC was 93%, 100%, 100%, 20% and 93.3% respectively. Conclusion:Accurately sampled FNA smears supplemented by cell-block preparation considerably improve the false positive or negative diagnosis.

Objective: To describe the demographic and histological features of salivary gland pathologies at tertiary care hospital. Study Design: Retrospective Descriptive. Setting: Shalamar Institute of Health Sciences, Lahore. Period: February 2012 to February 2017. Material & Method: 17548 surgical specimens were received during this period. Among these, 50 cases were diagnosed as salivary gland disorders. Statistical analysis was carried out using SPSS version 22. Results: 50 cases were diagnosed as salivary gland disorders out of 17548 surgical resections. Salivary gland disorders were divided into non-neoplastic group (n= 15) and neoplastic group (n = 35), which was further divided into: (i) Benign tumors, (n= 26) and (ii) Malignant tumors, (n= 9). Conclusion: Salivary gland disorders are rare diseases to be encountered clinically. Chronic sialadenitis among non-neoplastic disorders, pleomorphic adenoma among benign tumor and mucoepidermoid carcinoma among malignant tumors were the commonest.